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Science 5 July 1985:
Vol. 229. no. 4708, pp. 60 - 62
DOI: 10.1126/science.2990038
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Articles

Science, Vol 229, Issue 4708, 60-62
Copyright © 1985 by American Association for the Advancement of Science

articles

Reexamination of glucose-6-phosphatase activity in the brain in vivo: no evidence for a futile cycle

T Nelson, G Lucignani, S Atlas, AM Crane, GA Dienel, and L Sokoloff

Glucose-6-phosphatase activity in the rat brain in vivo was estimated by measuring the differential loss of tritium and carbon-14 from the glucose pool labeled by a mixture of [2-3H]glucose and [U-14C]glucose. The results provide no evidence of significant dephosphorylation of glucose-6-phosphate and do not support the hypothesis of a futile cycle involving glucose-6-phosphatase activity in the brain.


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