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Science 5 July 1985:
Vol. 229. no. 4708, pp. 52 - 54
DOI: 10.1126/science.4012310
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Articles

Science, Vol 229, Issue 4708, 52-54
Copyright © 1985 by American Association for the Advancement of Science

articles

Dominance in physiological phenotypes and fitness at an enzyme locus

TJ Hilbish and RK Koehn

Aminopeptidase-I allozymes, which are products of the Lap locus in the marine mussel, Mytilus edulis, differ in their catalytic efficiencies. These biochemical differences result in genotype-specific rates of change in the free amino acid pool, that is, cell volume regulation, when mussels are subjected to changes in salinity. A high degree of dominance was found among genotypes for these biochemical and physiological phenotypes. Selection models that incorporate dominance adequately predict observed genotypic properties at the Lap locus among natural populations that exhibit clinical allele frequency. This suggests that a high degree of dominance for fitness must also occur at this locus in natural populations. These results provide additional evidence that the maintenance of an allele frequency cline is operating by natural selection at the Lap locus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Geographic Structure in the European Flat Oyster (Ostrea edulis L.) as Revealed by Microsatellite Polymorphism.
S. Launey, C. Ledu, P. Boudry, F. Bonhomme, and Y. Naciri-Graven (2002)
J. Hered. 93, 331-351
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Balancing selection at allozyme loci in oysters: implications from nuclear RFLPs.
S. Karl and J. Avise (1992)
Science 256, 100-102
   Abstract »    PDF »
Functional and physiological consequences of genetic variation at phosphoglucose isomerase: Heat shock protein expression is related to enzyme genotype in a montane beetle.
E. P. Dahlhoff and N. E. Rank (2000)
PNAS 97, 10056-10061
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