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Science 5 July 1985:
Vol. 229. no. 4708, pp. 16 - 22
DOI: 10.1126/science.2990035
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Articles

Science, Vol 229, Issue 4708, 16-22
Copyright © 1985 by American Association for the Advancement of Science

articles

The granulocyte-macrophage colony-stimulating factors

D Metcalf

The granulocyte-macrophage colony-stimulating factors are well-characterized specific glycoproteins that interact to control the production, differentiation, and function of two related white cell populations of the blood, the granulocytes and monocyte-macrophages. Widely produced in the body, these regulators probably play an important role in resistance to infections. The proliferation of myeloid leukemia cells remains dependent on stimulation by colony-stimulating factors, although one of them also has the ability to suppress leukemic populations by inducing terminal differentiation.


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