Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 28 June 1985:
Vol. 228. no. 4707, pp. 1547 - 1549
DOI: 10.1126/science.3925551
Prev | Table of Contents | Next

Articles

Science, Vol 228, Issue 4707, 1547-1549
Copyright © 1985 by American Association for the Advancement of Science

articles

Localization of the gene encoding the human interleukin-2 receptor on chromosome 10

WJ Leonard, TA Donlon, RV Lebo, and WC Greene

The human interleukin-2 receptor is an inducible growth factor receptor present on the surface of activated T lymphocytes. The receptor is required for a normal T-cell immune response. High-resolution fluorescence-activated chromosome sorting and DNA spot-blot analysis with complementary DNA's for the interleukin-2 receptor indicated that the receptor gene was located on chromosome 9, 10, 11, or 12. In situ hybridization studies showed that the interleukin-2 receptor gene is on the short arm of chromosome 10, p14----15.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Molecular cloning and characterization of the human KIN17 cDNA encoding a component of the UVC response that is conserved among metazoans.
P. Kannouche, P. Mauffrey, G. Pinon-Lataillade, M. G. Mattei, A. Sarasin, L. Daya-Grosjean, and J. F. Angulo (2000)
Carcinogenesis 21, 1701-1710
   Abstract »    Full Text »    PDF »
Functional Characterization of the Human Interleukin-15 Receptor alpha Chain and Close Linkage of IL15RA and IL2RA Genes.
D. M. Anderson, S. Kumaki, M. Ahdieh, J. Bertles, M. Tometsko, A. Loomis, J. Giri, N. G. Copeland, D. J. Gilbert, N. A. Jenkins, et al. (1995)
J. Biol. Chem. 270, 29862-29869
   Abstract »    Full Text »    PDF »
Human T cell leukemia viruses use a receptor determined by human chromosome 17.
M. Sommerfelt, B. Williams, P. Clapham, E Solomon, P. Goodfellow, and R. Weiss (1988)
Science 242, 1557-1559
   Abstract »    PDF »
The Human Interleukin-2 Receptor: Normal and Abnormal Expression in T Cells and in Leukemias Induced by the Human T-Lymphotropic Retroviruses.
W. C. GREENE, W. J. LEONARD, J. M. DEPPER, D. L. NELSON, and T. A. WALDMANN (1986)
Ann Intern Med 105, 560-572
   Abstract »    PDF »
The Human Interleukin-2 Receptor: Role in Normal T-cell Growth and Association with HTLV-I-induced T-cell Leukemia.
W.C. Greene, J.M. Depper, M. Kronke, and W.J. Leonard (1986)
Cold Spring Harb Symp Quant Biol 51, 731-737
   Abstract »    PDF »
Structure of the human interleukin-2 receptor gene.
W. Leonard, J. Depper, M Kanehisa, M Kronke, N. Peffer, P. Svetlik, M Sullivan, and W. Greene (1985)
Science 230, 633-639
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)