Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 28 June 1985:
Vol. 228. no. 4707, pp. 1540 - 1543
DOI: 10.1126/science.2409597
Prev | Table of Contents | Next

Articles

Science, Vol 228, Issue 4707, 1540-1543
Copyright © 1985 by American Association for the Advancement of Science

articles

Analysis of T-cell receptor gene rearrangement and expression in human natural killer clones

J Ritz, TJ Campen, RE Schmidt, HD Royer, T Hercend, RE Hussey, and EL Reinherz

A series of clones of human natural killer (NK) cells was characterized with respect to expression of the Ti alpha and Ti beta genes of the T-cell receptor. T11+T3+ NK clones contained Ti alpha and Ti beta RNA transcripts and expressed disulfide-linked heterodimers, demonstrating the presence of a functional T-cell receptor. In contrast, T11+T3- NK clones expressed only 1.0-kilobase truncated Ti beta transcripts, without a Ti alpha transcript and no detectable surface Ti protein. Since previous studies demonstrated that Ti beta gene activation precedes Ti alpha gene activation in thymic ontogeny, the T11+T3- NK cells appear to be derived from T-lineage precursors.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Dysregulated NK receptor expression in patients with lymphoproliferative disease of granular lymphocytes.
P. K. Epling-Burnette, J. S. Painter, P. Chaurasia, F. Bai, S. Wei, J. Y. Djeu, and T. P. Loughran Jr (2004)
Blood 103, 3431-3439
   Abstract »    Full Text »    PDF »
T Cell and NK Cell Lymphoproliferative Disorders.
J. P. Greer, M. C. Kinney, and T. P. Loughran Jr. (2001)
Hematology 2001, 259-281
   Abstract »    Full Text »    PDF »
NKR-P1, a signal transduction molecule on natural killer cells.
R Giorda, W. Rudert, C Vavassori, W. Chambers, J. Hiserodt, and M Trucco (1990)
Science 249, 1298-1300
   Abstract »    PDF »
Severe Hypersensitivity to Mosquito Bites Associated With Natural Killer Cell Lymphocytosis.
Y. Tokura, Y. Tamura, M. Takigawa, M. Koide, T. Satoh, T. Sakamoto, D. Horiguchi, and M. Yamada (1990)
Arch Dermatol 126, 362-368
   Abstract »    PDF »
Identification of a T helper cell-derived lymphokine that activates resting T lymphocytes.
C Milanese, N. Richardson, and E. Reinherz (1986)
Science 231, 1118-1122
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)