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Science 28 June 1985:
Vol. 228. no. 4707, pp. 1534 - 1537
DOI: 10.1126/science.2990032
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Articles

Science, Vol 228, Issue 4707, 1534-1537
Copyright © 1985 by American Association for the Advancement of Science

articles

HTLV x-gene product: requirement for the env methionine initiation codon

W Wachsman, DW Golde, PA Temple, EC Orr, SC Clark, and IS Chen

The human T-cell leukemia viruses (HTLV) are replication-competent retroviruses whose genomes contain gag, pol, and env genes as well as a fourth gene, termed x, which is believed to be the transforming gene of HTLV. The product of the x gene is now shown to be encoded by a 2.1-kilobase messenger RNA derived by splicing of at least two introns. By means of S1 nuclease mapping of this RNA and nucleic acid sequence analysis of a complementary DNA clone, the complete primary structure of the x-gene product has been determined. It is encoded by sequences containing the env initiation codon and one nucleotide of the next codon spliced to the major open reading frame of the HTLV-I and HTLV-II x gene.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
HTLV-II transactivation is regulated by the overlapping tax/rex nonstructural genes.
J. Rosenblatt, A. Cann, D. Slamon, I. Smalberg, N. Shah, J Fujii, W Wachsman, and I. Chen (1988)
Science 240, 916-919
   Abstract »    PDF »
HTLV x gene mutants exhibit novel transcriptional regulatory phenotypes.
W Wachsman, A. Cann, J. Williams, D. Slamon, L Souza, N. Shah, and I. Chen (1987)
Science 235, 674-677
   Abstract »    PDF »
Trans-activator gene of HTLV-II induces IL-2 receptor and IL-2 cellular gene expression.
W. Greene, W. Leonard, Y Wano, P. Svetlik, N. Peffer, J. Sodroski, C. Rosen, W. Goh, and W. Haseltine (1986)
Science 232, 877-880
   Abstract »    PDF »
The Human Interleukin-2 Receptor: Role in Normal T-cell Growth and Association with HTLV-I-induced T-cell Leukemia.
W.C. Greene, J.M. Depper, M. Kronke, and W.J. Leonard (1986)
Cold Spring Harb Symp Quant Biol 51, 731-737
   Abstract »    PDF »
More about the HTLV's and how they act.
J. Marx (1985)
Science 229, 37-38
   PDF »
The x gene is essential for HTLV replication.
I. Chen, D. Slamon, J. Rosenblatt, N. Shah, S. Quan, and W Wachsman (1985)
Science 229, 54-58
   Abstract »    PDF »
Expression of the pX gene of HTLV-I: general splicing mechanism in the HTLV family.
M Seiki, A Hikikoshi, T Taniguchi, and M Yoshida (1985)
Science 228, 1532-1534
   Abstract »    PDF »


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