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Science 28 June 1985:
Vol. 228. no. 4707, pp. 1502 - 1507
DOI: 10.1126/science.2409596
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Articles

Science, Vol 228, Issue 4707, 1502-1507
Copyright © 1985 by American Association for the Advancement of Science

articles

Organization of ion channels in the myelinated nerve fiber

SG Waxman and JM Ritchie

The functional organization of the mammalian myelinated nerve fiber is complex and elegant. In contrast to nonmyelinated axons, whose membranes have a relatively uniform structure, the mammalian myelinated axon exhibits a high degree of regional specialization that extends to the location of voltage-dependent ion channels within the axon membrane. Sodium and potassium channels are segregated into complementary membrane domains, with a distribution reflecting that of the overlying Schwann or glial cells. This complexity of organization has important implications for physiology and pathophysiology, particularly with respect to the development of myelinated fibers.


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