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Science 28 June 1985:
Vol. 228. no. 4707, pp. 1496 - 1501
DOI: 10.1126/science.2990030
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Articles

Science, Vol 228, Issue 4707, 1496-1501
Copyright © 1985 by American Association for the Advancement of Science

articles

The unusual varl gene of yeast mitochondrial DNA

RA Butow, PS Perlman, and LI Grossman

The var1 gene specifies the only mitochondrial ribosomal protein known to be encoded by yeast mitochondrial DNA. The gene is unusual in that its base composition is nearly 90 percent adenine plus thymine. It and its expression product show a strain-dependent variation in size of up to 7 percent; this variation does not detectably interfere with function. Furthermore, var1 is an expandable gene that participates in a novel recombinational event resembling gene conversion whereby shorter alleles are preferentially converted to longer ones. The remarkable features of var1 indicate that it may have evolved by a mechanism analogous to exon shuffling, although no introns are actually present.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The ATP-dependent PIM1 protease is required for the expression of intron-containing genes in mitochondria.
L. van Dyck, W. Neupert, and T. Langer (1998)
Genes & Dev. 12, 1515-1524
   Abstract »    Full Text »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)