Science 21 June 1985: Vol. 228. no. 4706, pp. 1440 - 1443 DOI: 10.1126/science.3874430

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Articles

Context-dependent Bcl-2/Bak Interactions Regulate Lymphoid Cell Apoptosis.

H. Dai, X. W. Meng, S.-H. Lee, P. A. Schneider, and S. H. Kaufmann (2009)
J. Biol. Chem. 284, 18311-18322
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-2 Inhibitors: Targeting Mitochondrial Apoptotic Pathways in Cancer Therapy.

M. H. Kang and C. P. Reynolds (2009)
Clin. Cancer Res. 15, 1126-1132
 |  Abstract »  |  Full Text »  |  PDF »

Somatic hypermutation of IGVH genes and aberrant somatic hypermutation in follicular lymphoma without BCL-2 gene rearrangement and expression.

E. Gagyi, Z. Balogh, C. Bodor, B. Timar, L. Reiniger, L. Deak, J. Csomor, B. Csernus, A. Szepesi, and A. Matolcsy (2008)
Haematologica 93, 1822-1828
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Classification of lymphoid neoplasms: the microscope as a tool for disease discovery.

E. S. Jaffe, N. L. Harris, H. Stein, and P. G. Isaacson (2008)
Blood 112, 4384-4399
 |  Abstract »  |  Full Text »  |  PDF »

IL-4 protein expression and basal activation of Erk in vivo in follicular lymphoma.

K. R. Calvo, B. Dabir, A. Kovach, C. Devor, R. Bandle, A. Bond, J. H. Shih, and E. S. Jaffe (2008)
Blood 112, 3818-3826
 |  Abstract »  |  Full Text »  |  PDF »

Interactions between SIRT1 and AP-1 reveal a mechanistic insight into the growth promoting properties of alumina (Al2O3) nanoparticles in mouse skin epithelial cells.

S. Dey, V. Bakthavatchalu, M. T. Tseng, P. Wu, R. L. Florence, E. A. Grulke, R. A. Yokel, S. K. Dhar, H.-S. Yang, Y. Chen, et al. (2008)
Carcinogenesis 29, 1920-1929
 |  Abstract »  |  Full Text »  |  PDF »

The prevention of spontaneous apoptosis of follicular lymphoma B cells by a follicular dendritic cell line: involvement of caspase-3, caspase-8 and c-FLIP.

J.-J. Goval, C. Thielen, C. Bourguignon, R. Greimers, E. Dejardin, Y. S. Choi, J. Boniver, and L. de Leval (2008)
Haematologica 93, 1169-1177
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Age-Dependent Prevalence and Frequency of Circulating t(14;18)-Positive Cells in the Peripheral Blood of Healthy Individuals.

G. Dolken, L. Dolken, C. Hirt, C. Fusch, C. S. Rabkin, and F. Schuler (2008)
J Natl Cancer Inst Monographs 2008, 44-47
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Bcl-2-family proteins and hematologic malignancies: history and future prospects.

J. C. Reed (2008)
Blood 111, 3322-3330
 |  Abstract »  |  Full Text »  |  PDF »

Loss of Bcl-x in Ph+ B-ALL increases cellular proliferation and does not inhibit leukemogenesis.

J. G. Harb, B. I. Chyla, and C. S. Huettner (2008)
Blood 111, 3760-3769
 |  Abstract »  |  Full Text »  |  PDF »

Molecular Imaging of bcl-2 Expression in Small Lymphocytic Lymphoma Using 111In-Labeled PNA-Peptide Conjugates.

F. Jia, S. D. Figueroa, F. Gallazzi, B. S. Balaji, M. Hannink, S. Z. Lever, T. J. Hoffman, and M. R. Lewis (2008)
J. Nucl. Med. 49, 430-438
 |  Abstract »  |  Full Text »  |  PDF »

Acquired Resistance to Rituximab Is Associated with Chemotherapy Resistance Resulting from Decreased Bax and Bak Expression.

S. H. Olejniczak, F. J. Hernandez-Ilizaliturri, J. L. Clements, and M. S. Czuczman (2008)
Clin. Cancer Res. 14, 1550-1560
 |  Abstract »  |  Full Text »  |  PDF »

Oncogenes and Cancer.

C. M. Croce (2008)
N. Engl. J. Med. 358, 502-511
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BCL-2 Family Proteins: Critical Checkpoints of Apoptotic Cell Death.

N. N. Danial (2007)
Clin. Cancer Res. 13, 7254-7263
 |  Abstract »  |  Full Text »  |  PDF »

Cooperation of the proapoptotic receptor agonist rhApo2L/TRAIL with the CD20 antibody rituximab against non-Hodgkin lymphoma xenografts.

D. Daniel, B. Yang, D. A. Lawrence, K. Totpal, I. Balter, W. P. Lee, A. Gogineni, M. J. Cole, S. F. Yee, S. Ross, et al. (2007)
Blood 110, 4037-4046
 |  Abstract »  |  Full Text »  |  PDF »

Human Follicular Lymphoma Cells Contain Oligomannose Glycans in the Antigen-binding Site of the B-cell Receptor.

C. M. Radcliffe, J. N. Arnold, D. M. Suter, M. R. Wormald, D. J. Harvey, L. Royle, Y. Mimura, Y. Kimura, R. B. Sim, S. Inoges, et al. (2007)
J. Biol. Chem. 282, 7405-7415
 |  Abstract »  |  Full Text »  |  PDF »

Syk-dependent mTOR activation in follicular lymphoma cells.

L. Leseux, S. M. Hamdi, T. al Saati, F. Capilla, C. Recher, G. Laurent, and C. Bezombes (2006)
Blood 108, 4156-4162
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of Gene Rearrangements Leading to Activation of MDR-1.

L. M. Huff, J.-S. Lee, R. W. Robey, and T. Fojo (2006)
J. Biol. Chem. 281, 36501-36509
 |  Abstract »  |  Full Text »  |  PDF »

t(14;18) translocations in lymphocytes of healthy dioxin-exposed individuals from Seveso, Italy.

A. Baccarelli, C. Hirt, A. C. Pesatori, D. Consonni, D. G. Patterson Jr, P. A. Bertazzi, G. Dolken, and M. T. Landi (2006)
Carcinogenesis 27, 2001-2007
 |  Abstract »  |  Full Text »  |  PDF »

Prevalence of fragile histidine triad expression in tumors from saudi arabia: a tissue microarray analysis..

P. Bavi, Z. Jehan, V. Atizado, H. Al-Dossari, F. Al-Dayel, A. Tulbah, S. S. Amr, S. S. Sheikh, A. Ezzat, H. El-Solh, et al. (2006)
Cancer Epidemiol. Biomarkers Prev. 15, 1708-1718
 |  Abstract »  |  Full Text »  |  PDF »

Proteomic Analysis of the Extraembryonic Tissue from Cloned Porcine Embryos.

J.-I. Chae, S.-K. Cho, J.-W. Seo, T.-S. Yoon, K.-S. Lee, J.-H. Kim, K.-K. Lee, Y.-M. Han, and K. Yu (2006)
Mol. Cell. Proteomics 5, 1559-1566
 |  Abstract »  |  Full Text »  |  PDF »

Detection of the bcl-2 t(14;18) Translocation and Proto-Oncogene Expression in Primary Intraocular Lymphoma..

D. J. Wallace, D. Shen, G. F. Reed, M. Miyanaga, M. Mochizuki, H. N. Sen, S. S. Dahr, R. R. Buggage, R. B. Nussenblatt, and C.-C. Chan (2006)
Invest. Ophthalmol. Vis. Sci. 47, 2750-2756
 |  Abstract »  |  Full Text »  |  PDF »

RNA Aptamers Targeting the Cell Death Inhibitor CED-9 Induce Cell Killing in Caenorhabditis elegans.

C. Yang, N. Yan, J. Parish, X. Wang, Y. Shi, and D. Xue (2006)
J. Biol. Chem. 281, 9137-9144
 |  Abstract »  |  Full Text »  |  PDF »

Bcl-2 inhibition of autophagy: a new route to cancer?.

S. Pattingre and B. Levine (2006)
Cancer Res. 66, 2885-2888
 |  Abstract »  |  Full Text »  |  PDF »

Phase I to II Multicenter Study of Oblimersen Sodium, a Bcl-2 Antisense Oligonucleotide, in Patients With Advanced Chronic Lymphocytic Leukemia.

S. M. O'Brien, C. C. Cunningham, A. K. Golenkov, A. G. Turkina, S. C. Novick, and K. R. Rai (2005)
J. Clin. Oncol. 23, 7697-7702
 |  Abstract »  |  Full Text »  |  PDF »

miR-15 and miR-16 induce apoptosis by targeting BCL2.

A. Cimmino, G. A. Calin, M. Fabbri, M. V. Iorio, M. Ferracin, M. Shimizu, S. E. Wojcik, R. I. Aqeilan, S. Zupo, M. Dono, et al. (2005)
PNAS 102, 13944-13949
 |  Abstract »  |  Full Text »  |  PDF »

Familial risk for non-Hodgkin lymphoma and other lymphoproliferative malignancies by histopathologic subtype: the Swedish Family-Cancer Database.

A. Altieri, J. L. Bermejo, and K. Hemminki (2005)
Blood 106, 668-672
 |  Abstract »  |  Full Text »  |  PDF »

Targeting Apoptosis Pathways in Cancer Therapy.

I. M. Ghobrial, T. E. Witzig, and A. A. Adjei (2005)
CA Cancer J Clin 55, 178-194
 |  Abstract »  |  Full Text »  |  PDF »

The Mitochondrial Death Pathway and Cardiac Myocyte Apoptosis.

M. T. Crow, K. Mani, Y.-J. Nam, and R. N. Kitsis (2004)
Circ. Res. 95, 957-970
 |  Abstract »  |  Full Text »  |  PDF »

Quantitative PCR Detection of t(14;18) bcl-2/JH Fusion Sequences in Follicular Lymphoma Patients: Comparison of Peripheral Blood and Bone Marrow Aspirate Samples.

A. Bowman, D. Jones, L. J. Medeiros, and R. Luthra (2004)
J. Mol. Diagn. 6, 396-400
 |  Abstract »  |  Full Text »  |  PDF »

Activation of Apoptosis in Vivo by a Hydrocarbon-Stapled BH3 Helix.

L. D. Walensky, A. L. Kung, I. Escher, T. J. Malia, S. Barbuto, R. D. Wright, G. Wagner, G. L. Verdine, and S. J. Korsmeyer (2004)
Science 305, 1466-1470
 |  Abstract »  |  Full Text »  |  PDF »

BCL2 Translocation Defines a Unique Tumor Subset within the Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma.

J. Iqbal, W. G. Sanger, D. E. Horsman, A. Rosenwald, D. L. Pickering, B. Dave, S. Dave, L. Xiao, K. Cao, Q. Zhu, et al. (2004)
Am. J. Pathol. 165, 159-166
 |  Abstract »  |  Full Text »  |  PDF »

The Domains of Apoptosis: A Genomics Perspective.

J. C. Reed, K. S. Doctor, and A. Godzik (2004)
Sci. STKE 2004, re9
 |  Abstract »  |  Full Text »  |  PDF »

Apaf-1 and caspase-9 accelerate apoptosis, but do not determine whether factor-deprived or drug-treated cells die.

P. G. Ekert, S. H. Read, J. Silke, V. S. Marsden, H. Kaufmann, C. J. Hawkins, R. Gerl, S. Kumar, and D. L. Vaux (2004)
J. Cell Biol. 165, 835-842
 |  Abstract »  |  Full Text »  |  PDF »

Oblimersen Sodium (Genasense bcl-2 Antisense Oligonucleotide): A Rational Therapeutic to Enhance Apoptosis in Therapy of Lung Cancer.

R. S. Herbst and S. R. Frankel (2004)
Clin. Cancer Res. 10, 4245S-4248S
 |  Abstract »  |  Full Text »  |  PDF »

MCL-1 Promoter Insertions Dial-Up Aggressiveness of Chronic Leukemia.

S. Kitada and J. C. Reed (2004)
J Natl Cancer Inst 96, 642-643
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Prognostic significance of bcl-xL gene expression and apoptotic cell counts in follicular lymphoma.

W.-L. Zhao, M. E. Daneshpouy, N. Mounier, J. Briere, C. Leboeuf, L.-F. Plassa, E. Turpin, J.-M. Cayuela, J.-C. Ameisen, C. Gisselbrecht, et al. (2004)
Blood 103, 695-697
 |  Abstract »  |  Full Text »  |  PDF »

Identification of c-Jun as bcl-2 Transcription Factor in Human Uterine Endometrium.

Z. Li, H. Abe, K. Ueki, K. Kumagai, R. Araki, and Y. Otsuki (2003)
J. Histochem. Cytochem. 51, 1601-1609
 |  Abstract »  |  Full Text »  |  PDF »

BCL6 gene translocation in follicular lymphoma: a harbinger of eventual transformation to diffuse aggressive lymphoma.

T. Akasaka, I. S. Lossos, and R. Levy (2003)
Blood 102, 1443-1448
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis and Related Proteins in Placenta of Intrauterine Fetal Death in Prostaglandin F Receptor-Deficient Mice.

J. Mu, T. Kanzaki, X. Si, T. Tomimatsu, H. Fukuda, M. Shioji, Y. Murata, Y. Sugimoto, and A. Ichikawa (2003)
Biol Reprod 68, 1968-1974
 |  Abstract »  |  Full Text »  |  PDF »

Par-4 Transcriptionally Regulates Bcl-2 through a WT1-binding Site on the bcl-2 Promoter.

S. K. Cheema, S. K. Mishra, V. M. Rangnekar, A. M. Tari, R. Kumar, and G. Lopez-Berestein (2003)
J. Biol. Chem. 278, 19995-20005
 |  Abstract »  |  Full Text »  |  PDF »

Cell cycle deregulation in B-cell lymphomas.

M. Sanchez-Beato, A. Sanchez-Aguilera, and M. A. Piris (2003)
Blood 101, 1220-1235
 |  Abstract »  |  Full Text »  |  PDF »

Survivin, bcl-2, bax, and bcl-X Gene Expression in Sentinel Lymph Nodes From Melanoma Patients.

A. Gradilone, P. Gazzaniga, D. Ribuffo, S. Scarpa, E. Cigna, F. Vasaturo, U. Bottoni, D. Innocenzi, S. Calvieri, N. Scuderi, et al. (2003)
J. Clin. Oncol. 21, 306-312
 |  Abstract »  |  Full Text »  |  PDF »

Primary Follicular Lymphoma of the Small Intestine: {alpha}4{beta}7 Expression and Immunoglobulin Configuration Suggest an Origin from Local Antigen-Experienced B Cells.

R. J. Bende, L. A. Smit, J. G. Bossenbroek, W. M. Aarts, M. Spaargaren, L. de Leval, G. E. E. Boeckxstaens, S. T. Pals, and C. J. M. van Noesel (2003)
Am. J. Pathol. 162, 105-113
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of Glucocorticoid-induced Apoptosis in 697 Pre-B Lymphocytes by the Mineralocorticoid Receptor N-terminal Domain.

S. L. Planey, A. Derfoul, A. Steplewski, N. M. Robertson, and G. Litwack (2002)
J. Biol. Chem. 277, 42188-42196
 |  Abstract »  |  Full Text »  |  PDF »

Effects of microinjection of synthetic Bcl-2 domain peptides on apoptosis of renal tubular epithelial cells.

E. Peherstorfer, B. Mayer, S. Boehm, A. Lukas, P. Hauser, G. Mayer, and R. Oberbauer (2002)
Am J Physiol Renal Physiol 283, F190-F196
 |  Abstract »  |  Full Text »  |  PDF »

Immune escape of tumors: apoptosis resistance and tumor counterattack.

F. H. Igney and P. H. Krammer (2002)
J. Leukoc. Biol. 71, 907-920
 |  Abstract »  |  Full Text »  |  PDF »

Programmed cell death takes flight: genetic and genomic approaches to gene discovery in Drosophila.

S. Gorski and M. Marra (2002)
Physiol Genomics 9, 59-69
 |  Abstract »  |  Full Text »  |  PDF »

In situ localization of follicular lymphoma: description and analysis by laser capture microdissection.

P. Cong, M. Raffeld, J. Teruya-Feldstein, L. Sorbara, S. Pittaluga, and E. S. Jaffe (2002)
Blood 99, 3376-3382
 |  Abstract »  |  Full Text »  |  PDF »

Acquisition of potential N-glycosylation sites in the immunoglobulin variable region by somatic mutation is a distinctive feature of follicular lymphoma.

D. Zhu, H. McCarthy, C. H. Ottensmeier, P. Johnson, T. J. Hamblin, and F. K. Stevenson (2002)
Blood 99, 2562-2568
 |  Abstract »  |  Full Text »  |  PDF »

Clinicopathologic analysis of follicular lymphoma occurring in children.

R. B. Lorsbach, D. Shay-Seymore, J. Moore, P. M. Banks, R. P. Hasserjian, J. T. Sandlund, and F. G. Behm (2002)
Blood 99, 1959-1964
 |  Abstract »  |  Full Text »  |  PDF »

Tumor cell dissemination in follicular lymphoma.

S. Oeschger, A. Brauninger, R. Kuppers, and M.-L. Hansmann (2002)
Blood 99, 2192-2198
 |  Abstract »  |  Full Text »  |  PDF »

Detection of BCL2 Rearrangements in Follicular Lymphoma.

J. C. Aster and J. A. Longtine (2002)
Am. J. Pathol. 160, 759-763
 |  Abstract »  |  Full Text »  |  PDF »

Regulation of Cell Proliferation, Apoptosis, and Carcinogenesis by Activin.

Y.-G. Chen, H. M. Lui, S.-L. Lin, J. M. Lee, and S.-Y. Ying (2002)
Experimental Biology and Medicine 227, 75-87
 |  Abstract »  |  Full Text »  |  PDF »

Update on Epidemiology and Therapeutics for Non-Hodgkin's Lymphoma.

J. M. Vose, B. C.-H. Chiu, B. D. Cheson, J. Dancey, and J. Wright (2002)
Hematology 2002, 241-262
 |  Abstract »  |  Full Text »

Gene expression profiling of follicular lymphoma and normal germinal center B cells using cDNA arrays.

H. Husson, E. G. Carideo, D. Neuberg, J. Schultze, O. Munoz, P. W. Marks, J. W. Donovan, A. C. Chillemi, P. O'Connell, and A. S. Freedman (2002)
Blood 99, 282-289
 |  Abstract »  |  Full Text »  |  PDF »

Human bcl-2 Gene Attenuates the Ability of Rabbit Lens Epithelial Cells against H2O2-induced Apoptosis through Down-regulation of the alpha B-crystallin Gene.

Y.-W. Mao, H. Xiang, J. Wang, S. Korsmeyer, J. Reddan, and D. W.-C. Li (2001)
J. Biol. Chem. 276, 43435-43445
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis and Aging: Role of the Mitochondria.

M. Pollack and C. Leeuwenburgh (2001)
J. Gerontol. A Biol. Sci. Med. Sci. 56, B475-482
 |  Abstract »  |  Full Text »  |  PDF »

How can we prevent cancer?.

C. M. Croce (2001)
PNAS 98, 10986-10988
 |  Full Text »  |  PDF »

Characterization of the 13q14 Tumor Suppressor Locus in CLL: Identification of ALT1, an Alternative Splice Variant of the LEU2 Gene.

F. Bullrich, H. Fujii, G. Calin, H. Mabuchi, M. Negrini, Y. Pekarsky, L. Rassenti, H. Alder, J. C. Reed, M. J. Keating, et al. (2001)
Cancer Res. 61, 6640-6648
 |  Abstract »  |  Full Text »  |  PDF »

Cell Cycle-mediated Drug Resistance: An Emerging Concept in Cancer Therapy.

M. A. Shah and G. K. Schwartz (2001)
Clin. Cancer Res. 7, 2168-2181
 |  Abstract »  |  Full Text »  |  PDF »

Endothelial Apoptosis Induced by Oxidative Stress Through Activation of NF-{kappa}B: Antiapoptotic Effect of Antioxidant Agents on Endothelial Cells.

M. Aoki, T. Nata, R. Morishita, H. Matsushita, H. Nakagami, K. Yamamoto, K. Yamazaki, M. Nakabayashi, T. Ogihara, and Y. Kaneda (2001)
Hypertension 38, 48-55
 |  Abstract »  |  Full Text »  |  PDF »

Clinicopathologic, Immunophenotypic, and Molecular Characterization of Primary Cutaneous Follicular B-Cell Lymphoma.

R. Bergman, P. J. Kurtin, L. E. Gibson, P. R. Hull, T. K. Kimlinger, and A. L. Schroeter (2001)
Arch Dermatol 137, 432-439
 |  Abstract »  |  Full Text »  |  PDF »

Primary Cutaneous Follicular Lymphoma.

L. Cerroni and H. Kerl (2001)
Arch Dermatol 137, 489-490
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Two Cases of Non-Hodgkin's Lymphoma in First Degree Relatives.

I. Ota, K. Shinohara, K. Muraki, N. Fukuda, T. Takahashi, R. Nawata, and Y. Shimohakamada (2000)
Jpn. J. Clin. Oncol. 30, 571-573
 |  Abstract »  |  Full Text »  |  PDF »

The role of apoptosis, proliferation, and the Bcl-2-related proteins in the myelodysplastic syndromes and acute myeloid leukemia secondary to MDS.

J. E. Parker, G. J. Mufti, F. Rasool, A. Mijovic, S. Devereux, and A. Pagliuca (2000)
Blood 96, 3932-3938
 |  Abstract »  |  Full Text »  |  PDF »

Characterization of the Molecular Mechanisms for p53-mediated Differentiation.

K. Chylicki, M. Ehinger, H. Svedberg, and U. Gullberg (2000)
Cell Growth Differ. 11, 561-571
 |  Abstract »  |  Full Text »

Mechanisms of Apoptosis.

J. C. Reed (2000)
Am. J. Pathol. 157, 1415-1430
 |  Abstract »  |  Full Text »  |  PDF »

Correlation between Bcl-2 Overexpression and H-ras Mutation in Naturally Occurring Hepatocellular Proliferative Lesions of the B6C3F1 Mouse.

M. Iida, H. Iwata, H. Inoue, M. Enomoto, N. Horie, and K. Takeishi (2000)
Toxicol. Sci. 56, 297-302
 |  Abstract »  |  Full Text »  |  PDF »

Differential Expression of Bcl-2 Homologs in Human CD34+ Hematopoietic Progenitor Cells Induced to Differentiate into Erythroid or Granulocytic Cells.

D. Josefsen, J. H. Myklebust, J. Lømo, M. Sioud, H. K. Blomhoff, and E. B. Smeland (2000)
Stem Cells 18, 261-272
 |  Abstract »  |  Full Text »

Primary cutaneous follicle center cell lymphoma with follicular growth pattern.

L. Cerroni, E. Arzberger, B. Putz, G. Hofler, D. Metze, C. A. Sander, C. Rose, P. Wolf, A. Rutten, J. M. McNiff, et al. (2000)
Blood 95, 3922-3928
 |  Abstract »  |  Full Text »  |  PDF »

Hypoxia-Induced Endothelial Apoptosis Through Nuclear Factor-{kappa}B (NF-{kappa}B)-Mediated bcl-2 Suppression : In Vivo Evidence of the Importance of NF-{kappa}B in Endothelial Cell Regulation.

H. Matsushita, R. Morishita, T. Nata, M. Aoki, H. Nakagami, Y. Taniyama, K. Yamamoto, J. Higaki, K. Yasufumi, and T. Ogihara (2000)
Circ. Res. 86, 974-981
 |  Abstract »  |  Full Text »  |  PDF »

Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load.

W. M. Aarts, R. J. Bende, E. J. Steenbergen, P. M. Kluin, E. C. M. Ooms, S. T. Pals, and C. J. M. van Noesel (2000)
Blood 95, 2922-2929
 |  Abstract »  |  Full Text »  |  PDF »

Apoptosis in cancer.

S. W. Lowe and A. W. Lin (2000)
Carcinogenesis 21, 485-495
 |  Abstract »  |  Full Text »  |  PDF »

Tetrocarcin A Inhibits Mitochondrial Functions of Bcl-2 and Suppresses Its Anti-apoptotic Activity.

T. Nakashima, M. Miura, and M. Hara (2000)
Cancer Res. 60, 1229-1235
 |  Abstract »  |  Full Text »

Up-Regulation of the Proapoptotic Mediators Bax and Bak after Adenovirus-mediated p53 Gene Transfer in Lung Cancer Cells.

A. S. Pearson, F. R. Spitz, S. G. Swisher, M. Kataoka, M. G. Sarkiss, R. E. Meyn, T. J. McDonnell, R. J. Cristiano, and J. A. Roth (2000)
Clin. Cancer Res. 6, 887-890
 |  Abstract »  |  Full Text »

Modulated Binding of SATB1, a Matrix Attachment Region Protein, to the AT-Rich Sequence Flanking the Major Breakpoint Region of BCL2.

M. Ramakrishnan, W.-M. Liu, P. A. DiCroce, A. Posner, J. Zheng, T. Kohwi-Shigematsu, and T. G. Krontiris (2000)
Mol. Cell. Biol. 20, 868-877
 |  Abstract »  |  Full Text »

The IgG Fc receptor, Fcgamma RIIB, is a target for deregulation by chromosomal translocation in malignant lymphoma.

M. B. Callanan, P. Le Baccon, P. Mossuz, S. Duley, C. Bastard, R. Hamoudi, M. J. Dyer, G. Klobeck, R. Rimokh, J. J. Sotto, et al. (2000)
PNAS 97, 309-314
 |  Abstract »  |  Full Text »  |  PDF »

BCL-2 Is Phosphorylated and Inactivated by an ASK1/Jun N-Terminal Protein Kinase Pathway Normally Activated at G2/M.

K. Yamamoto, H. Ichijo, and S. J. Korsmeyer (1999)
Mol. Cell. Biol. 19, 8469-8478
 |  Abstract »  |  Full Text »  |  PDF »

Mechanisms of Transcriptional Activation of bcl-2 Gene Expression by 17beta -Estradiol in Breast Cancer Cells.

L. Dong, W. Wang, F. Wang, M. Stoner, J. C. Reed, M. Harigai, I. Samudio, M. P. Kladde, C. Vyhlidal, and S. Safe (1999)
J. Biol. Chem. 274, 32099-32107
 |  Abstract »  |  Full Text »  |  PDF »

Safety, Pharmacokinetics, and Tissue Distribution of Liposomal P-Ethoxy Antisense Oligonucleotides Targeted to Bcl-2.

Y. Gutiérrez-Puente, A. M. Tari, C. Stephens, M. Rosenblum, R. T. Guerra, and G. Lopez-Berestein (1999)
J. Pharmacol. Exp. Ther. 291, 865-869
 |  Abstract »  |  Full Text »

Dysregulation of Apoptosis in Cancer.

J. C. Reed (1999)
J. Clin. Oncol. 17, 2941
 |  Abstract »  |  Full Text »  |  PDF »

Altered bcl-2 family expression during non-genotoxic hepatocarcinogenesis in mice.

J. G. Christensen, E. H. Romach, L. N. Healy, A. J. Gonzales, S. P. Anderson, D. E. Malarkey, J. C. Corton, T. R. Fox, R. C. Cattley, and T. L. Goldsworthy (1999)
Carcinogenesis 20, 1583-1590
 |  Abstract »  |  Full Text »  |  PDF »

Hypermethylation of the DAP-Kinase CpG Island Is a Common Alteration in B-Cell Malignancies.

R. A. Katzenellenbogen, S. B. Baylin, and J. G. Herman (1999)
Blood 93, 4347-4353
 |  Abstract »  |  Full Text »  |  PDF »

Changes in Bcl-2 and Bax Expression in Rat Tongue during 4-Nitroquinoline 1-oxide-induced Carcinogenesis.

A. Nishimura (1999)
Journal of Dental Research 78, 1264-1269
 |  Abstract »  |  PDF »

p53 Suppresses the Activation of the Bcl-2 Promoter by the Brn-3a POU Family Transcription Factor.

V. Budhram-Mahadeo, P. J. Morris, M. D. Smith, C. A. Midgley, L. M. Boxer, and D. S. Latchman (1999)
J. Biol. Chem. 274, 15237-15244
 |  Abstract »  |  Full Text »  |  PDF »

Analysis of the p53/BAX Pathway in Colorectal Cancer: Low BAX Is a Negative Prognostic Factor in Patients With Resected Liver Metastases.

I. Sturm, C.-H. Kohne, G. Wolff, H. Petrowsky, T. Hillebrand, S. Hauptmann, M. Lorenz, B. Dorken, and P. T. Daniel (1999)
J. Clin. Oncol. 17, 1364
 |  Abstract »  |  Full Text »  |  PDF »

Role of FHIT in Human Cancer.

C. M. Croce, G. Sozzi, and K. Huebner (1999)
J. Clin. Oncol. 17, 1618
 |  Abstract »  |  Full Text »  |  PDF »

ATP-dependent Steps in Apoptotic Signal Transduction.

Y. Eguchi, A. Srinivasan, K. J. Tomaselli, S. Shimizu, and Y. Tsujimoto (1999)
Cancer Res. 59, 2174-2181
 |  Abstract »  |  Full Text »  |  PDF »

Expression of Bcl-2 and Its Homologues in Human Eosinophils . Modulation by Interleukin-5.

G. Dewson, G. M. Walsh, and A. J. Wardlaw (1999)
Am. J. Respir. Cell Mol. Biol. 20, 720-728
 |  Abstract »  |  Full Text »

Development and Validation of a Quantitative Polymerase Chain Reaction Assay to Evaluate Minimal Residual Disease for T-Cell Acute Lymphoblastic Leukemia and Follicular Lymphoma.

G. A. Hosler, R. O. Bash, X. Bai, V. Jain, and R. H. Scheuermann (1999)
Am. J. Pathol. 154, 1023-1035
 |  Abstract »  |  Full Text »  |  PDF »

Inhibition of p53 Transcriptional Activity by Bcl-2 Requires Its Membrane-anchoring Domain.

B. A. Froesch, C. Aime-Sempe, B. Leber, D. Andrews, and J. C. Reed (1999)
J. Biol. Chem. 274, 6469-6475
 |  Abstract »  |  Full Text »  |  PDF »

Inverse relationship between apoptosis and Bcl-2 expression in syncytiotrophoblast and fibrin-type fibrinoid in early gestation.

T. Toki, A. Horiuchi, N. Ichikawa, A. Mori, T. Nikaido, and S. Fujii (1999)
Mol. Hum. Reprod. 5, 246-251
 |  Abstract »  |  Full Text »  |  PDF »

IAP family proteins---suppressors of apoptosis.

Q. L. Deveraux and J. C. Reed (1999)
Genes & Dev. 13, 239-252
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Apoptosis during Breast Carcinoma Progression.

M. Vakkala, K. Lahteenmaki, H. Raunio, P. Paakko, and Y. Soini (1999)
Clin. Cancer Res. 5, 319-324
 |  Abstract »  |  Full Text »  |  PDF »

Androgens Down-Regulate bcl-2 Protooncogene Expression in ZR-75-1 Human Breast Cancer Cells.

J. Lapointe, A. Fournier, V. Richard, and C. Labrie (1999)
Endocrinology 140, 416-421
 |  Abstract »  |  Full Text »

WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation.

Y. Hu, L. Ding, D. M. Spencer, and G. Nunez (1998)
J. Biol. Chem. 273, 33489-33494
 |  Abstract »  |  Full Text »  |  PDF »

Actinobacillus actinomycetemcomitans Toxin Induces Both Cell Cycle Arrest in the G2/M Phase and Apoptosis.

M. Ohguchi, A. Ishisaki, N. Okahashi, M. Koide, T. Koseki, K. Yamato, T. Noguchi, and T. Nishihara (1998)
Infect. Immun. 66, 5980-5987
 |  Abstract »  |  Full Text »  |  PDF »

Suppression of c-Myc-Induced Apoptosis by the Epstein-Barr Virus Gene Product BHRF1.

A. Fanidi, D. C. Hancock, and T. D. Littlewood (1998)
J. Virol. 72, 8392-8395
 |  Abstract »  |  Full Text »  |  PDF »

Histopathological Evaluation of Apoptosis in Cancer.

Y. Soini, P. Paakko, and V-P. Lehto (1998)
Am. J. Pathol. 153, 1041-1053
 |  Full Text »  |  PDF »

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