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Science 21 June 1985:
Vol. 228. no. 4706, pp. 1427 - 1430
DOI: 10.1126/science.2990027
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Articles

Science, Vol 228, Issue 4706, 1427-1430
Copyright © 1985 by American Association for the Advancement of Science

articles

Studies of the putative transforming protein of the type I human T-cell leukemia virus

DJ Slamon, MF Press, LM Souza, DC Murdock, MJ Cline, DW Golde, JC Gasson, and IS Chen

The putative transforming protein of the type I human T-cell leukemia virus (HTLV-1) is a 40-kilodalton protein encoded by the X region and is termed p40XI. On the basis of both subcellular fractionation techniques and immunocytochemical analysis, it is now shown that p40XI is a nuclear protein with a relatively short half-life (120 minutes). It is synthesized de novo in considerable quantities in a human T-cell line infected with and transformed by the virus in vitro, and it is not packaged in detectable amounts in the extracellular virus.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Construction and Characterization of a Full-Length Infectious Simian T-Cell Lymphotropic Virus Type 3 Molecular Clone.
S. A. Chevalier, M. Walic, S. Calattini, A. Mallet, M.-C. Prevost, A. Gessain, and R. Mahieux (2007)
J. Virol. 81, 6276-6285
   Abstract »    Full Text »    PDF »
A 10-Amino Acid Domain within Human T-cell Leukemia Virus Type 1 and Type 2 Tax Protein Sequences Is Responsible for Their Divergent Subcellular Distribution.
L. Meertens, S. Chevalier, R. Weil, A. Gessain, and R. Mahieux (2004)
J. Biol. Chem. 279, 43307-43320
   Abstract »    Full Text »    PDF »
Binding of p53 to the KIX Domain of CREB Binding Protein. A POTENTIAL LINK TO HUMAN T-CELL LEUKEMIA VIRUS, TYPE I-ASSOCIATED LEUKEMOGENESIS.
K. Van Orden, H. A. Giebler, I. Lemasson, M. Gonzales, and J. K. Nyborg (1999)
J. Biol. Chem. 274, 26321-26328
   Abstract »    Full Text »    PDF »
Metabolic Labeling of Woodchuck Hepatitis B Virus X Protein in Naturally Infected Hepatocytes Reveals a Bimodal Half-Life and Association with the Nuclear Framework.
M. Dandri, J. Petersen, R. J. Stockert, T. M. Harris, and C. E. Rogler (1998)
J. Virol. 72, 9359-9364
   Abstract »    Full Text »    PDF »
Identification and characterization of the protein encoded by the human N-myc oncogene.
D. Slamon, T. Boone, R. Seeger, D. Keith, V Chazin, H. Lee, and L. Souza (1986)
Science 232, 768-772
   Abstract »    PDF »
Functional relation between HTLV-II x and adenovirus E1A proteins in transcriptional activation.
I. Chen, A. Cann, N. Shah, and R. Gaynor (1985)
Science 230, 570-573
   Abstract »    PDF »
More about the HTLV's and how they act.
J. Marx (1985)
Science 229, 37-38
   PDF »
The x gene is essential for HTLV replication.
I. Chen, D. Slamon, J. Rosenblatt, N. Shah, S. Quan, and W Wachsman (1985)
Science 229, 54-58
   Abstract »    PDF »


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