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Science 7 June 1985:
Vol. 228. no. 4704, pp. 1204 - 1206
DOI: 10.1126/science.3839095
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Articles

Science, Vol 228, Issue 4704, 1204-1206
Copyright © 1985 by American Association for the Advancement of Science

articles

A novel mechanism of somatic rearrangement predicted by a human T-cell antigen receptor beta-chain complementary DNA

AD Duby, KA Klein, C Murre, and JG Seidman

The T-cell antigen receptor is a cell surface molecule vital in mediating the cellular immune response. The arrangement and rearrangement of the gene segments encoding the beta-chain polypeptide of the receptor are similar to those of immunoglobulin gene segments. The two constant region genes of the human T-cell antigen receptor are 8 kilobases apart with a cluster of joining segments located 5' of each constant region gene. Although most beta-chain gene rearrangements involve the variable, diversity, and joining segments, analysis of a beta-chain complementary DNA clone suggests the occasional occurrence of another type of rearrangement.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)