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Science 7 June 1985:
Vol. 228. no. 4704, pp. 1201 - 1204
DOI: 10.1126/science.3159089

Articles

Science, Vol 228, Issue 4704, 1201-1204
Copyright © 1985 by American Association for the Advancement of Science


articles

Isolation of T-cell tropic HTLV-III-like retrovirus from macaques

MD Daniel, NL Letvin, NW King, M Kannagi, PK Sehgal, RD Hunt, PJ Kanki, M Essex, and RC Desrosiers

The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of acquired immune deficiency syndrome in humans (HTLV-III or LAV). This virus is referred to as simian T-lymphotropic virus type III (STLV-III) of macaques. The existence of a cytopathic, T-cell tropic virus resembling HTLV-III in monkeys may facilitate study of disease induction and vaccine development in an animal model.


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E. Khatissian, V. Monceaux, M.-C. Cumont, M.-P. Kieny, A.-M. Aubertin, and B. Hurtrel (2001)
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Dilated Cardiomyopathy Associated With Simian AIDS in Nonhuman Primates.
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Circulation 101, 185-193
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J. Virol. 74, 619-626
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Conserved MHC Class I Peptide Binding Motif Between Humans and Rhesus Macaques.
J. L. Dzuris, J. Sidney, E. Appella, R. W. Chesnut, D. I. Watkins, and A. Sette (2000)
J. Immunol. 164, 283-291
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Specific passage of simian immunodeficiency virus fromend-stage disease results in accelerated progression to AIDS in rhesus macaques.
L. Holterman, H. Niphuis, P. J. F. ten Haaft, J. Goudsmit, G. Baskin, and J. L. Heeney (1999)
J. Gen. Virol. 80, 3089-3097
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Species-Specific, Postentry Barriers to Primate Immunodeficiency Virus Infection.
W. Hofmann, D. Schubert, J. LaBonte, L. Munson, S. Gibson, J. Scammell, P. Ferrigno, and J. Sodroski (1999)
J. Virol. 73, 10020-10028
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Experimental Infection of Rhesus and Pig-Tailed Macaques with Macaque Rhadinoviruses.
K. G. Mansfield, S. V. Westmoreland, C. D. DeBakker, S. Czajak, A. A. Lackner, and R. C. Desrosiers (1999)
J. Virol. 73, 10320-10328
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Protection by Live, Attenuated Simian Immunodeficiency Virus against Heterologous Challenge.
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J. Virol. 73, 8356-8363
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Postinoculation PMPA Treatment, but Not Preinoculation Immunomodulatory Therapy, Protects against Development of Acute Disease Induced by the Unique Simian Immunodeficiency Virus SIVsmmPBj.
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J. Virol. 73, 8630-8639
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Primary Human Immunodeficiency Virus Type 2 (HIV-2) Isolates Infect CD4-Negative Cells via CCR5 and CXCR4: Comparison with HIV-1 and Simian Immunodeficiency Virus and Relevance to Cell Tropism In Vivo.
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J. Virol. 73, 7795-7804
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Shortening of the Symptom-Free Period in Rhesus Macaques Is Associated with Decreasing Nonsynonymous Variation in the env Variable Regions of Simian Immunodeficiency Virus SIVsm during Passage.
P. J. S. Valli, V. V. Lukashov, J. L. Heeney, and J. Goudsmit (1998)
J. Virol. 72, 7494-7500
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Characterization of the Peptide Binding Motif of a Rhesus MHC Class I Molecule (Mamu-A*01) That Binds an Immunodominant CTL Epitope from Simian Immunodeficiency Virus.
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J. Immunol. 160, 6062-6071
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Simian Immunodeficiency Virus Replicates to High Levels in Sooty Mangabeys without Inducing Disease.
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J. Virol. 72, 3872-3886
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J. Virol. 72, 1983-1993
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J. Virol. 72, 405-414
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Molecular cloning of a feline leukemia virus that induces fatal immunodeficiency disease in cats.
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The human immunodeficiency virus: infectivity and mechanisms of pathogenesis.
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Science 232, 238-243
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Nucleotide sequence of SRV-1, a type D simian acquired immune deficiency syndrome retrovirus.
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Science 231, 1567-1572
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A new HTLV-III/LAV encoded antigen detected by antibodies from AIDS patients.
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Antigens of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus.
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Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III.
P. Kanki, M. McLane, N. King Jr, N. Letvin, R. Hunt, P Sehgal, M. Daniel, R. Desrosiers, and M Essex (1985)
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