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Science 7 June 1985:
Vol. 228. no. 4704, pp. 1199 - 1201
DOI: 10.1126/science.3873705
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Articles

Science, Vol 228, Issue 4704, 1199-1201
Copyright © 1985 by American Association for the Advancement of Science

articles

Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III

PJ Kanki, MF McLane, NW King Jr, NL Letvin, RD Hunt, P Sehgal, MD Daniel, RC Desrosiers, and M Essex

Human T-lymphotropic virus type III (HTLV-III) is thought to play an etiologic role in the development of the acquired immune deficiency syndrome (AIDS). In this study the serologic characterization of a new simian retrovirus that is related to HTLV-III is described. This new virus, here referred to as STLV-III, was isolated from sick macaques at the New England Regional Primate Research Center. Radioimmunoprecipitation analysis revealed STLV-III-specific proteins of 160, 120, 55, and 24 kilodaltons, all similar in size to the major gag and env proteins of HTLV-III. These antigens were recognized by representative macaque serum samples and human reference serum samples positive for HTLV-III antibodies. Monoclonal antibodies directed to p24, the major core protein of HTLV-III, also immunoprecipitated a 24-kilodalton species in lysates of cells infected with the macaque virus. This HTLV-III-related virus, which naturally infects a nonhuman primate species, may provide a useful model for the study of HTLV-III and the pathogenesis of AIDS.


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