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Science 7 June 1985:
Vol. 228. no. 4704, pp. 1169 - 1175
DOI: 10.1126/science.4001935
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Articles

Science, Vol 228, Issue 4704, 1169-1175
Copyright © 1985 by American Association for the Advancement of Science

articles

Evolution in inbred strains of mice appears rapid

WM Fitch and WR Atchley

Genetic variation at 97 loci in ten commonly used inbred strains of mice is greatly in excess of that expected under current assumptions. Evidence against all of the readily apparent explanations is presented and the possibility of early selection for heterozygosity or of conversion is suggested. The common ancestor of these strains is estimated to have occurred about 150 years ago.


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