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Science 31 May 1985:
Vol. 228. no. 4703, pp. 1091 - 1094
DOI: 10.1126/science.2986290
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Articles

Science, Vol 228, Issue 4703, 1091-1094
Copyright © 1985 by American Association for the Advancement of Science

articles

Major glycoprotein antigens that induce antibodies in AIDS patients are encoded by HTLV-III

JS Allan, JE Coligan, F Barin, MF McLane, JG Sodroski, CA Rosen, WA Haseltine, TH Lee, and M Essex

Antibodies from the serum of patients with the acquired immune deficiency syndrome (AIDS) or with the AIDS-related complex and from the serum of seropositive healthy homosexuals, recognize two major glycoproteins in cells infected with human T-cell lymphotropic virus type III (HTLV III). These glycoproteins, gp160 and gp120, are encoded by the 2.5-kilobase open reading frame located in the 3' end of the HTLV-III genome, as determined by amino terminus sequence analysis of the radiolabeled forms of these proteins. It is hypothesized that gp160 and gp120 represent the major species of virus-encoded envelope gene products for HTLV-III.


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   Abstract »    PDF »
Antiserum to a synthetic peptide recognizes the HTLV-III envelope glycoprotein.
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Science 231, 1556-1559
   Abstract »    PDF »
Characterization of highly immunogenic p66/p51 as the reverse transcriptase of HTLV-III/LAV.
F di Marzo Veronese, T. Copeland, A. DeVico, R Rahman, S Oroszlan, R. Gallo, and M. Sarngadharan (1986)
Science 231, 1289-1291
   Abstract »    PDF »
Binding of HTLV-III/LAV to T4+ T cells by a complex of the 110K viral protein and the T4 molecule.
J. McDougal, M. Kennedy, J. Sligh, S. Cort, A Mawle, and J. Nicholson (1986)
Science 231, 382-385
   Abstract »    PDF »
Isolation of T-lymphotropic retrovirus related to HTLV-III/LAV from wild-caught African green monkeys.
P. Kanki, J Alroy, and M Essex (1985)
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   Abstract »    PDF »
Antigens of Human T-Lymphotropic Virus Type III/Lymphadenopathy-Associated Virus.
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Ann Intern Med 103, 700-703
   Abstract »    PDF »
Characterization of gp41 as the transmembrane protein coded by the HTLV-III/LAV envelope gene.
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   Abstract »    PDF »
Serologic identification and characterization of a macaque T-lymphotropic retrovirus closely related to HTLV-III.
P. Kanki, M. McLane, N. King Jr, N. Letvin, R. Hunt, P Sehgal, M. Daniel, R. Desrosiers, and M Essex (1985)
Science 228, 1199-1201
   Abstract »    PDF »
Virus envelope protein of HTLV-III represents major target antigen for antibodies in AIDS patients.
F Barin, M. McLane, J. Allan, T. Lee, J. Groopman, and M Essex (1985)
Science 228, 1094-1096
   Abstract »    PDF »
Expression, Purification, and Characterization of gp160e, the Soluble, Trimeric Ectodomain of the Simian Immunodeficiency Virus Envelope Glycoprotein, gp160.
B. Chen, G. Zhou, M. Kim, Y. Chishti, R. E. Hussey, B. Ely, J. J. Skehel, E. L. Reinherz, S. C. Harrison, and D. C. Wiley (2000)
J. Biol. Chem. 275, 34946-34953
   Abstract »    Full Text »    PDF »


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