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Science 24 May 1985:
Vol. 228. no. 4702, pp. 1007 - 1009
DOI: 10.1126/science.3859011
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Articles

Science, Vol 228, Issue 4702, 1007-1009
Copyright © 1985 by American Association for the Advancement of Science

articles

Stimulation of bone resorption in vitro by synthetic transforming growth factor-alpha

KJ Ibbotson, DR Twardzik, SM D'Souza, WR Hargreaves, GJ Todaro, and GR Mundy

Experiments were conducted to test the hypothesis that tumor-derived transforming growth factor-alpha (TGF-alpha) is responsible for the increased bone resorption and hypercalcemia seen in some malignant diseases. Homogeneous synthetic TGF-alpha prepared by the solid-phase synthesis method stimulated bone resorption directly in vitro in a concentration-dependent manner. Incubation times of 72 hours or more were required to stimulate resorption, which is similar to the time course of bone resorption by epidermal growth factor.


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