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Science 17 May 1985:
Vol. 228. no. 4701, pp. 885 - 889
DOI: 10.1126/science.4001925
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Articles

Science, Vol 228, Issue 4701, 885-889
Copyright © 1985 by American Association for the Advancement of Science

articles

Matrix-driven translocation of cells and nonliving particles

SA Newman, DA Frenz, JJ Tomasek, and DD Rabuzzi

Cells of metazoan organisms produce and react to complex macromolecular microenvironments known as extracellular matrices. Assembly in vitro of native, compositionally nonuniform collagen-fibronectin matrices caused translocation of certain types of cells or polystyrene-latex beads from regions lacking fibronectin into regions containing it. The translocation process was not due to diffusion, convection, or electrostatic distribution effects, but may depend on nonequilibrium phenomena at the interface of contiguous collagen matrices formed in the presence and absence of fibronectin or particles. Extracellular matrix formation alone was sufficient to drive translocation by a biophysical process that may play a role in cellular migration during embryogenesis, as well as in other types of tissue reorganization such as inflammation, wound healing, and tumor invasion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Collagen Fibril Flow and Tissue Translocation Coupled to Fibroblast Migration in 3D Collagen Matrices.
M. Miron-Mendoza, J. Seemann, and F. Grinnell (2008)
Mol. Biol. Cell 19, 2051-2058
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Borrelia burgdorferi Binds to, Invades, and Colonizes Native Type I Collagen Lattices.
M. C. Zambrano, A. A. Beklemisheva, A. V. Bryksin, S. A. Newman, and F. C. Cabello (2004)
Infect. Immun. 72, 3138-3146
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Interaction of the NH2-terminal Domain of Fibronectin with Heparin. ROLE OF THE Omega -LOOPS OF THE TYPE I MODULES.
R. Kishore, M. Samuel, M. Y. Khan, J. Hand, D. A. Frenz, and S. A. Newman (1997)
J. Biol. Chem. 272, 17078-17085
   Abstract »    Full Text »    PDF »
On the possible role of cytoskeletal filamentous networks in intracellular signaling: an approach based on percolation.
G Forgacs (1995)
J. Cell Sci. 108, 2131-2143
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Expression and functional involvement of N-cadherin in embryonic limb chondrogenesis.
S. Oberlender and R. Tuan (1994)
Development 120, 177-187
   Abstract »    PDF »
Directed Movement of Latex Particles in the Gynoecia of Three Species of Flowering Plants.
L. C. SANDERS and E. M. LORD (1989)
Science 243, 1606-1608
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