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Science 17 May 1985:
Vol. 228. no. 4701, pp. 815 - 822
DOI: 10.1126/science.2988123
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Articles

Science, Vol 228, Issue 4701, 815-822
Copyright © 1985 by American Association for the Advancement of Science

articles

The LDL receptor gene: a mosaic of exons shared with different proteins

TC Sudhof, JL Goldstein, MS Brown, and DW Russell

The multifunctional nature of coated pit receptors predicts that these proteins will contain multiple domains. To establish the genetic basis for these domains (LDL) receptor. This gene is more than 45 kilobases in length and contains 18 exons, most of which correlate with functional domains previously defined at the protein level. Thirteen of the 18 exons encode protein sequences that are homologous to sequences in other proteins: five of these exons encode a sequence similar to one in the C9 component of complement; three exons encode a sequence similar to a repeat sequence in the precursor for epidermal growth factor (EGF) and in three proteins of the blood clotting system (factor IX, factor X, and protein C); and five other exons encode nonrepeated sequences that are shared only with the EGF precursor. The LDL receptor appears to be a mosaic protein built up of exons shared with different proteins, and it therefore belongs to several supergene families.


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An antiviral soluble form of the LDL receptor induced by interferon.
D. Fischer, N Tal, D Novick, S Barak, and M Rubinstein (1993)
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Neurexins: synaptic cell surface proteins related to the alpha-latrotoxin receptor and laminin.
Y. Ushkaryov, A. Petrenko, M Geppert, and T. Sudhof (1992)
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Expression pattern of Motch, a mouse homolog of Drosophila Notch, suggests an important role in early postimplantation mouse development.
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Neurexins.
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How big is the universe of exons?.
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Science 250, 1377-1382
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Diet-induced hypercholesterolemia in mice: prevention by overexpression of LDL receptors.
M Yokode, R. Hammer, S Ishibashi, M. Brown, and J. Goldstein (1990)
Science 250, 1273-1275
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Intracellular targeting and structural conservation of a prohormone-processing endoprotease.
R. Fuller, A. Brake, and J Thorner (1989)
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Synapsins: mosaics of shared and individual domains in a family of synaptic vesicle phosphoproteins.
T. Sudhof, A. Czernik, H. Kao, K Takei, P. Johnston, A Horiuchi, S. Kanazir, M. Wagner, M. Perin, P De Camilli, et al. (1989)
Science 245, 1474-1480
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Transcriptionally Defective Retroviruses Containing lacZ for the In Situ Detection of Endogenous Genes and Developmentally Regulated Chromatin.
W.G. Kerr, G.P. Nolan, A.T. Serafini, and L.A. Herzenberg (1989)
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Delta, a Drosophila neurogenic gene, is transcriptionally complex and encodes a protein related to blood coagulation factors and epidermal growth factor of vertebrates..
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Genes & Dev. 2, 1723-1735
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A synaptic vesicle protein with a novel cytoplasmic domain and four transmembrane regions.
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Science 238, 1142-1144
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The Exon Theory of Genes.
W. Gilbert (1987)
Cold Spring Harb Symp Quant Biol 52, 901-905
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What Introns Have to Tell Us: Hierarchy in Genome Evolution.
W.F. Doolittle (1987)
Cold Spring Harb Symp Quant Biol 52, 907-913
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Exon and Domain Evolution in the Proenzymes of Blood Coagulation and Fibrinolysis.
C.C.F. Blake, K. Harlos, and S.K. Holland (1987)
Cold Spring Harb Symp Quant Biol 52, 925-931
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Science 232, 1230-1237
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A receptor-mediated pathway for cholesterol homeostasis.
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Science 232, 34-47
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The LDL Receptor in Familial Hypercholesterolemia: Use of Human Mutations to Dissect a Membrane Protein.
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Cold Spring Harb Symp Quant Biol 51, 811-819
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Cold Spring Harb Symp Quant Biol 51, 959-966
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Science 230, 633-639
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Science 230, 37-43
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Cassette of eight exons shared by genes for LDL receptor and EGF precursor.
T. Sudhof, D. Russell, J. Goldstein, M. Brown, R Sanchez-Pescador, and G. Bell (1985)
Science 228, 893-895
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