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Science 10 May 1985:
Vol. 228. no. 4700, pp. 752 - 755
DOI: 10.1126/science.3838821
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Articles

Science, Vol 228, Issue 4700, 752-755
Copyright © 1985 by American Association for the Advancement of Science

articles

Widespread distribution of brain dopamine receptors evidenced with [125I]iodosulpride, a highly selective ligand

MP Martres, ML Bouthenet, N Sales, P Sokoloff, and JC Schwartz

The new benzamide derivative [125I]iodosulpride is a highly sensitive and selective ligand for D-2 dopamine receptors and displays a very low nonspecific binding to membrane or autoradiographic sections. On autoradiographic images, D-2 receptors are present not only in well-established dopaminergic areas but also, in a discrete manner, in a number of catecholaminergic regions in which the dopaminergic innervation is still unknown, imprecise, or controversial, as in the sensorimotor cerebral cortex or cerebellum. This widespread distribution suggests larger physiological and pathophysiological roles for cerebral dopamine receptors than was previously thought.


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