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Science 10 May 1985:
Vol. 228. no. 4700, pp. 733 - 737
DOI: 10.1126/science.3922054
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Articles

Science, Vol 228, Issue 4700, 733-737
Copyright © 1985 by American Association for the Advancement of Science

articles

Human immunoglobulin D: genomic sequence of the delta heavy chain

MB White, AL Shen, CJ Word, PW Tucker, and FR Blattner

The DNA coding for the human immunoglobulin D(IgD) heavy chain (delta, delta) has been sequenced including the membrane and secreted termini. Human delta, like that of the mouse, has a separate exon for the carboxyl terminus of the secreted form. This feature of human and mouse IgD distinguishes it from all other immunoglobulins regardless of species or class. The human gene is different from that of the mouse; it has three, rather than two, constant region domains; and its lengthy hinge is encoded by two exons rather than one. Except for the third constant region, the human and mouse genes are only distantly related.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Porcine Ig {delta} Gene: Unique Chimeric Splicing of the First Constant Region Domain in its Heavy Chain Transcripts.
Y. Zhao, Q. Pan-Hammarstrom, I. Kacskovics, and L. Hammarstrom (2003)
J. Immunol. 171, 1312-1318
   Abstract »    Full Text »    PDF »
Artiodactyl IgD: The Missing Link.
Y. Zhao, I. Kacskovics, Q. Pan, D. A. Liberles, J. Geli, S. K. Davis, H. Rabbani, and L. Hammarstrom (2002)
J. Immunol. 169, 4408-4416
   Abstract »    Full Text »    PDF »
The Immunoglobulin Heavy Chain Locus of the Duck. GENOMIC ORGANIZATION AND EXPRESSION OF D, J, AND C REGION GENES.
M. L. Lundqvist, D. L. Middleton, S. Hazard, and G. W. Warr (2001)
J. Biol. Chem. 276, 46729-46736
   Abstract »    Full Text »    PDF »
Immunoglobulin D: Properties, Measurement, and Clinical Relevance.
A. O. Vladutiu (2000)
Clin. Vaccine Immunol. 7, 131-140
   Full Text »    PDF »
Th2 cytokine dependence of IgD production by normal human B cells.
I. Levan-Petit, E. Lelievre, A. Barra, A. Limosin, B. Gombert, J.-L. Preud'homme, and J.-C. Lecron (1999)
Int. Immunol. 11, 1819-1828
   Abstract »    Full Text »    PDF »
A novel chimeric Ig heavy chain from a teleost fish shares similarities to IgD.
M. Wilson, E. Bengten, N. W. Miller, L. W. Clem, L. Du Pasquier, and G. W. Warr (1997)
PNAS 94, 4593-4597
   Abstract »    Full Text »    PDF »
Molecular analysis of the t(2;14) translocation of childhood chronic lymphocytic leukemia.
H. Fell, R. Smith, and P. Tucker (1986)
Science 232, 491-494
   Abstract »    PDF »


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