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Science 10 May 1985:
Vol. 228. no. 4700, pp. 722 - 724
DOI: 10.1126/science.2986287
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Articles

Science, Vol 228, Issue 4700, 722-724
Copyright © 1985 by American Association for the Advancement of Science

articles

Individual tumors of multifocal EB virus-induced malignant lymphomas in tamarins arise from different B-cell clones

ML Cleary, MA Epstein, S Finerty, RF Dorfman, GW Bornkamm, JK Kirkwood, AJ Morgan, and J Sklar

Cotton-top tamarins were inoculated with sufficient Epstein-Barr virus to induce multiple tumors in each animal within 14 to 21 days. The tumors consisted of large-cell lymphomas that contained multiple copies of the Epstein-Barr virus genome and generated Epstein-Barr virus-carrying cell lines showing no detectable consistent chromosomal abnormality. Hybridization of tumor DNA with immunoglobulin gene probes revealed that each lymphoma was oligo- or monoclonal in origin and that individual tumors from the same animal arose from different B-cell clones. Thus the virus induced multiple transformation events in tamarins in vivo to cause malignant tumors resembling the Epstein-Barr virus-associated lymphomas of patients with organ transplants.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Experimental Infection of NOD/SCID Mice Reconstituted with Human CD34+ Cells with Epstein-Barr Virus.
M. Islas-Ohlmayer, A. Padgett-Thomas, R. Domiati-Saad, M. W. Melkus, P. D. Cravens, M. d. P. Martin, G. Netto, and J. V. Garcia (2004)
J. Virol. 78, 13891-13900
   Abstract »    Full Text »    PDF »
Primary Immune Responses by Cord Blood CD4+ T Cells and NK Cells Inhibit Epstein-Barr Virus B-Cell Transformation In Vitro.
A. D. Wilson and A. J. Morgan (2002)
J. Virol. 76, 5071-5081
   Abstract »    Full Text »    PDF »
The expression and function of Epstein-Barr virus encoded latent genes.
L S Young, C W Dawson, and A G Eliopoulos (2000)
Mol. Pathol. 53, 238-247
   Abstract »    Full Text »
Expression of BARF1 Gene Encoded by Epstein-Barr Virus in Nasopharyngeal Carcinoma Biopsies.
G. Decaussin, F. Sbih-Lammali, Mireille de Turenne-Tessier, A. Bouguermouh, and T. Ooka (2000)
Cancer Res. 60, 5584-5588
   Abstract »    Full Text »
Human Cd4+ T Lymphocytes Consistently Respond to the Latent Epstein-Barr Virus Nuclear Antigen Ebna1.
C. Munz, K. L. Bickham, M. Subklewe, M. L. Tsang, A. Chahroudi, M. G. Kurilla, D. Zhang, M. O'Donnell, and R. M. Steinman (2000)
J. Exp. Med. 191, 1649-1660
   Abstract »    Full Text »    PDF »


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