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Science 3 May 1985:
Vol. 228. no. 4699, pp. 600 - 603
DOI: 10.1126/science.3983646
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Articles

Science, Vol 228, Issue 4699, 600-603
Copyright © 1985 by American Association for the Advancement of Science

articles

Regenerating fish optic nerves and a regeneration-like response in injured optic nerves of adult rabbits

M Schwartz, M Belkin, A Harel, A Solomon, V Lavie, M Hadani, I Rachailovich, and C Stein-Izsak

Regeneration of fish optic nerve (representing regenerative central nervous system) was accompanied by increased activity of regeneration-triggering factors produced by nonneuronal cells. A graft of regenerating fish optic nerve, or a "wrap-around" implant containing medium conditioned by it, induced a response associated with regeneration in injured optic nerves of adult rabbits (representing a nonregenerative central nervous system). This response was manifested by an increase of general protein synthesis and of selective polypeptides in the retinas and by the ability of the retina to sprout in culture.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
A Purine-Sensitive Pathway Regulates Multiple Genes Involved in Axon Regeneration in Goldfish Retinal Ganglion Cells.
B. Petrausch, R. Tabibiazar, T. Roser, Y. Jing, D. Goldman, C. A. O. Stuermer, N. Irwin, and L. I. Benowitz (2000)
J. Neurosci. 20, 8031-8041
   Abstract »    Full Text »    PDF »
Recovery of visual response of injured adult rat optic nerves treated with transglutaminase.
S Eitan, A Solomon, V Lavie, E Yoles, D. Hirschberg, M Belkin, and M Schwartz (1994)
Science 264, 1764-1768
   Abstract »    PDF »


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Science. ISSN 0036-8075 (print), 1095-9203 (online)