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Science 3 May 1985:
Vol. 228. no. 4699, pp. 591 - 593
DOI: 10.1126/science.3983644
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Articles

Science, Vol 228, Issue 4699, 591-593
Copyright © 1985 by American Association for the Advancement of Science

articles

Ethanol neurotoxicity: effects on neurite formation and neurotrophic factor production in vitro

KE Dow and RJ Riopelle

The effects of ethanol on chick embryo sensory and spinal cord neurons growing on one of several biological substrates (poly-D-lysine, laminin, or neuron-produced neurite-promoting materials) were examined. Ethanol inhibited process formation by the neurons in a dose-dependent manner and inhibited the production of neurotrophic factors. Neuronal attachment to the substrates, survival of attached neurons, and receptor interactions of sensory neurons with nerve growth factor were not influenced by ethanol. It appears that ethanol alters certain metabolic characteristics of developing neurons.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling.
S. Chen and M. E. Charness (2008)
PNAS 105, 19962-19967
   Abstract »    Full Text »    PDF »
Ethanol inhibits L1-mediated neurite outgrowth in postnatal rat cerebellar granule cells..
C. F. Bearer, A. R. Swick, M. A. O'Riordan, and G. Cheng (1999)
J. Biol. Chem. 274, 20046
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Ethanol Inhibits L1-mediated Neurite Outgrowth in Postnatal Rat Cerebellar Granule Cells.
C. F. Bearer, A. R. Swick, M. A. O'Riordan, and G. Cheng (1999)
J. Biol. Chem. 274, 13264-13270
   Abstract »    Full Text »    PDF »


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