Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 3 May 1985:
Vol. 228. no. 4699, pp. 582 - 585
DOI: 10.1126/science.3983642
Prev | Table of Contents | Next

Articles

Science, Vol 228, Issue 4699, 582-585
Copyright © 1985 by American Association for the Advancement of Science

articles

Genes for beta chain of human T-cell antigen receptor map to regions of chromosomal rearrangement in T cells

CC Morton, AD Duby, RL Eddy, TB Shows, and JG Seidman

The T-cell antigen receptor is a cell-surface molecule that participates in the immune response. In the present experiments the genes encoding the beta chain of the T-cell receptor were found to reside on the long arm of human chromosome 7 at or near band q32. Related sequences were found on the short arm of chromosome 7 in bands p15-21 in some experiments. Chromosomal rearrangements in T-cells from normal individuals and patients with ataxia telangiectasia have previously been observed at and near these map assignments for the beta-chain genes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diagnostic role of tests for T cell receptor (TCR) genes.
E Hodges, M T Krishna, C Pickard, and J L Smith (2003)
J. Clin. Pathol. 56, 1-11
   Abstract »    Full Text »    PDF »
Frequency and Prognostic Significance of Clonal T-Cell Receptor {beta}-Gene Rearrangements in the Peripheral Blood of Patients With Mycosis Fungoides.
V. Bakels, J. W. van Oostveen, R. L. J. Gordijn, J. M. M. Walboomers, C. J. L. M. Meijer, and R. Willemze (1992)
Arch Dermatol 128, 1602-1607
   Abstract »    PDF »
Differentiation-linked leukemogenesis in lymphocytes.
M. Greaves (1986)
Science 234, 697-704
   Abstract »    PDF »
Mapping of the Cystic Fibrosis Locus on Chromosome 7.
L.-C. Tsui, S. Zengerling, H.F. Willard, and M. Buchwald (1986)
Cold Spring Harb Symp Quant Biol 51, 325-335
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)