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Science 3 May 1985:
Vol. 228. no. 4699, pp. 577 - 580
DOI: 10.1126/science.3885396
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Articles

Science, Vol 228, Issue 4699, 577-580
Copyright © 1985 by American Association for the Advancement of Science

articles

Expression of a microinjected porcine class I major histocompatibility complex gene in transgenic mice

WI Frels, JA Bluestone, RJ Hodes, MR Capecchi, and DS Singer

A porcine class I major histocompatibility complex (SLA) gene has been introduced into the genome of a C57BL/10 mouse. This transgenic mouse expressed SLA antigen on its cell surfaces and transmitted the gene to offspring, in which the gene is also expressed. Skin grafts of such transgenic mice were rejected by normal C57BL/10 mice, suggesting that the foreign SLA antigen expressed in the transgenic mice is recognized as a functional transplantation antigen.


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A T Lymphocyte-Specific Transcription Complex Containing RUNX1 Activates MHC Class I Expression.
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Distinct Transcriptional Pathways Regulate Basal and Activated Major Histocompatibility Complex Class I Expression.
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Transgenic animals.
R Jaenisch (1988)
Science 240, 1468-1474
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Science. ISSN 0036-8075 (print), 1095-9203 (online)