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Science 26 April 1985:
Vol. 228. no. 4698, pp. 495 - 497
DOI: 10.1126/science.2984772
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Articles

Science, Vol 228, Issue 4698, 495-497
Copyright © 1985 by American Association for the Advancement of Science

articles

Protection of mice against fatal herpes simplex type 2 infection by liposomes containing muramyl tripeptide

WC Koff, SD Showalter, B Hampar, and IJ Fidler

Intravenous administration of liposomes containing muramyl tripeptide phosphatidylethanolamine, a lipophilic derivative of muramyl dipeptide that activates macrophages to a cytolytic state in situ, significantly protected mice against lethal challenge with herpes simplex virus type 2. These findings suggest that the systemic activation of macrophages by liposomes containing an immunomodulator can lead to prophylaxis of severe infections caused by herpesviruses.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Diverting intracellular trafficking of Salmonella to the lysosome through activation of the late endocytic Rab7 by intracellular delivery of muramyl dipeptide.
K. Mukherjee, S. Parashuraman, G. Krishnamurthy, J. Majumdar, A. Yadav, R. Kumar, S. K. Basu, and A. Mukhopadhyay (2002)
J. Cell Sci. 115, 3693-3701
   Abstract »    Full Text »    PDF »
Single-Organism Model of Host Defense against Infection: A Novel Immunotoxicologic Approach to Evaluate Immunomodulatory Drugs.
D. J. Herzyk, E. V. Ruggieri, L. Cunningham, R. Polsky, C. Herold, A. M. Klinkner, A. Badger, W. D. Kerns, and P. J. Bugelski (1997)
Toxicol Pathol 25, 351-362
   Abstract »    PDF »
Development and testing of AIDS vaccines.
W. Koff and D. Hoth (1988)
Science 241, 426-432
   Abstract »    PDF »


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