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Science 19 April 1985:
Vol. 228. no. 4697, pp. 346 - 348
DOI: 10.1126/science.2580350
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Articles

Science, Vol 228, Issue 4697, 346-348
Copyright © 1985 by American Association for the Advancement of Science

articles

Selective extraction of small and large molecules from the cerebrospinal fluid by Purkinje neurons

LF Borges, PJ Elliott, R Gill, SD Iversen, and LL Iversen

Cerebellar Purkinje neurons accumulated propidium iodide, granular blue, and horseradish peroxidase conjugated to wheat germ agglutinin but not unconjugated horseradish peroxidase, bisbenzimide, or Evans blue when these compounds were infused into the lateral cerebral ventricles of awake, unrestrained rats. Accumulation of propidium iodide by Purkinje neurons of the vermis was associated with a reproducible behavioral abnormality characterized by truncal tremor, ataxia, and nystagmus. Both the accumulation of propidium iodide in Purkinje cells and the behavioral abnormality were prevented by prior intracerebroventricular administration of ouabain or colchicine, drugs that block neuronal transport processes. The ability of cerebellar Purkinje neurons to extract small and large molecules from the cerebrospinal fluid has important implications for their physiology and pathology.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Induction and Survival of Binucleated Purkinje Neurons by Selective Damage and Aging.
L. Magrassi, P. Grimaldi, A. Ibatici, M. Corselli, L. Ciardelli, S. Castello, M. Podesta, F. Frassoni, and F. Rossi (2007)
J. Neurosci. 27, 9885-9892
   Abstract »    Full Text »    PDF »
The cytoplasmic Purkinje onconeural antigen cdr2 down-regulates c-Myc function: implications for neuronal and tumor cell survival.
H. J. Okano, W.-Y. Park, J. P. Corradi, and R. B. Darnell (1999)
Genes & Dev. 13, 2087-2097
   Abstract »    Full Text »
Cerebellar ataxia with glutamic acid decarboxylase autoantibodies.
M. Abele, M. Weller, S. Mescheriakov, K. Burk, J. Dichgans, and T. Klockgether (1999)
Neurology 52, 857
   Abstract »    Full Text »
Anti-Purkinje Cell Antibody Producing B-Cell Lines From a Patient With Paraneoplastic Cerebellar Degeneration.
T. Tsukamoto, O. Yoshie, K. Tada, and Y. Iwasaki (1987)
Arch Neurol 44, 833-837
   Abstract »    PDF »


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