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Science 19 April 1985:
Vol. 228. no. 4697, pp. 323 - 325
DOI: 10.1126/science.3157217
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Articles

Science, Vol 228, Issue 4697, 323-325
Copyright © 1985 by American Association for the Advancement of Science

articles

Alignment of rat cardionatrin sequences with the preprocardionatrin sequence from complementary DNA

TG Flynn, PL Davies, BP Kennedy, ML de Bold, and AJ de Bold

Mammalian atria contain peptides that promote the excretion of salt and water from the kidney. When rat atrial tissue is extracted under conditions known to inhibit proteolysis, four natriuretic peptides, cardionatrins I to IV, are consistently isolated. These peptides derive from a common precursor, preprocardionatrin, of 152 amino acids, whose sequence was determined by DNA sequencing of a complementary DNA clone. Amino acid sequencing located the start points of cardionatrins I, III, and IV in the overall sequence. Cardionatrin IV most closely resembles procardionatrin because it begins immediately after the signal sequence at residue 25. Cardionatrin III begins at residue 73, and cardionatrin I, sequenced previously, begins at residue 123. Compositional analysis indicated that each of these cardionatrins extends up to tyrosine at position 150 but lacks the terminal two arginine residues.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)