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Science 19 April 1985:
Vol. 228. no. 4697, pp. 320 - 322
DOI: 10.1126/science.2580348
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Articles

Science, Vol 228, Issue 4697, 320-322
Copyright © 1985 by American Association for the Advancement of Science

articles

The product of the c-fms proto-oncogene: a glycoprotein with associated tyrosine kinase activity

CW Rettenmier, JH Chen, MF Roussel, and CJ Sherr

The c-fms proto-oncogene is a member of a gene family that has been implicated in tumorigenesis. Glycoproteins encoded by c-fms were identified in cat spleen cells by means of an immune-complex kinase assay performed with monoclonal antibodies to v-fms-coded epitopes. The major form of the normal cellular glycoprotein has an apparent molecular weight of 170,000 and, like the product of the viral oncogene, serves as a substrate for an associated tyrosine-specific protein kinase activity in vitro. The results suggest that the transforming glycoprotein specified by v-fms is a truncated form of a c-fms-coded growth factor receptor.


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Evidence for the involvement of GM-CSF and FMS in the deletion (5q) in myeloid disorders.
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