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Science 12 April 1985:
Vol. 228. no. 4696, pp. 190 - 192
DOI: 10.1126/science.3919445
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Articles

Science, Vol 228, Issue 4696, 190-192
Copyright © 1985 by American Association for the Advancement of Science

articles

Inhibition of calcification of bioprosthetic heart valves by local controlled-release diphosphonate

RJ Levy, J Wolfrum, FJ Schoen, MA Hawley, SA Lund, and R Langer

Bioprostheses fabricated from porcine aortic valves are widely used to replace diseased heart valves. Calcification is the principal cause of the clinical failure of these devices. In the present study, inhibition of the calcification of bioprosthetic heart valve cusps implanted subcutaneously in rats was achieved through the adjacent implantation of controlled-release matrices containing the anticalcification agent ethanehydroxydiphosphonate dispersed in a copolymer of ethylene-vinyl acetate. Prevention of calcification was virtually complete, without the adverse effects of retarded bone and somatic growth that accompany systemic administration of ethanehydroxydiphosphonate.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Prevention of Calcification of Bioprosthetic Heart Valve Cusp and Aortic Wall With Ethanol and Aluminum Chloride.
J. N. Clark, M. F. Ogle, P. Ashworth, R. W. Bianco, and R. J. Levy (2005)
Ann. Thorac. Surg. 79, 897-904
   Abstract »    Full Text »    PDF »
Assessment of Pericardium in Cardiac Bioprostheses: A Review.
J. M. G. Paez and E. Jorge-Herrero (1999)
J Biomater Appl 13, 351-388
   Abstract »    PDF »
Reduction of Calcification by Various Treatments in Cardiac Valves.
K. P. Rao and C. Shanthi (1999)
J Biomater Appl 13, 238-268
   Abstract »    PDF »
Bisphosphonates: Mechanisms of Action.
H. Fleisch (1998)
Endocr. Rev. 19, 80-100
   Abstract »    Full Text »
Prevention of Bioprosthetic Heart Valve Calcification by Ethanol Preincubation: Efficacy and Mechanisms.
N. Vyavahare, D. Hirsch, E. Lerner, J. Z. Baskin, F. J. Schoen, R. Bianco, H. S. Kruth, R. Zand, and R. J. Levy (1997)
Circulation 95, 479-488
   Abstract »    Full Text »
New challenges in biomaterials.
N. Peppas and R Langer (1994)
Science 263, 1715-1720
   Abstract »    PDF »
New methods of drug delivery.
R Langer (1990)
Science 249, 1527-1533
   Abstract »    PDF »
Controlled Release of Diphosphonates from Synthetic Polymers to Inhibit Calcification.
G. Golomb (1987)
J Biomater Appl 2, 266-289
   Abstract »    PDF »


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