Science 12 April 1985: Vol. 228. no. 4696, pp. 187 - 190 DOI: 10.1126/science.2579435

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Articles

Methionine Synthase A2756G Polymorphism Interacts with Alcohol and Folate Intake to Influence the Risk of Colorectal Adenoma.

T. Yamaji, M. Iwasaki, S. Sasazuki, H. Sakamoto, T. Yoshida, and S. Tsugane (2009)
Cancer Epidemiol. Biomarkers Prev. 18, 267-274
 |  Abstract »  |  Full Text »  |  PDF »

Differential expression of the embryo/cancer gene ECSA(DPPA2), the cancer/testis gene BORIS and the pluripotency structural gene OCT4, in human preimplantation development.

M. Monk, M. Hitchins, and S. Hawes (2008)
Mol. Hum. Reprod. 14, 347-355
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Silent Assassin: Oncogenic Ras Directs Epigenetic Inactivation of Target Genes.

X. Cheng (2008)
Science Signaling 1, pe14
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Mouse Skin Models for Carcinogenic Hazard Identification: Utilities and Challenges.

D. Lynch, J. Svoboda, S. Putta, H. E. J. Hofland, W. H. Chern, and L. A. Hansen (2007)
Toxicol Pathol 35, 853-864
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Alterations of DNA methylation associated with abnormalities of DNA methyltransferases in human cancers during transition from a precancerous to a malignant state.

Y. Kanai and S. Hirohashi (2007)
Carcinogenesis 28, 2434-2442
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The Cables Gene on Chromosome 18q Is Silenced by Promoter Hypermethylation and Allelic Loss in Human Colorectal Cancer.

D. Y. Park, H. Sakamoto, S. D. Kirley, S. Ogino, T. Kawasaki, E. Kwon, M. Mino-Kenudson, G. Y. Lauwers, D. C. Chung, B. R. Rueda, et al. (2007)
Am. J. Pathol. 171, 1509-1519
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Methylation of estrogen receptor {alpha} and mutL homolog 1 in normal colonic mucosa: association with folate and vitamin B-12 status in subjects with and without colorectal neoplasia.

R. Al-Ghnaniem, J. Peters, R. Foresti, N. Heaton, and M. Pufulete (2007)
Am. J. Clinical Nutrition 86, 1064-1072
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Does hyperhomocysteinaemia contribute to gastric carcinogenesis in Helicobacter pylori infected patients? * Author's reply.

L Peyrin-Biroulet, J.-L. Gueant, A M C Rocha, G A Rocha, M C A Marino, and D M M Queiroz (2007)
Gut 56, 1480-1481
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Older Age and Dietary Folate Are Determinants of Genomic and p16-Specific DNA Methylation in Mouse Colon.

M. K. Keyes, H. Jang, J. B. Mason, Z. Liu, J. W. Crott, D. E. Smith, S. Friso, and S.-W. Choi (2007)
J. Nutr. 137, 1713-1717
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Folic Acid for the Prevention of Colorectal Adenomas: A Randomized Clinical Trial.

B. F. Cole, J. A. Baron, R. S. Sandler, R. W. Haile, D. J. Ahnen, R. S. Bresalier, G. McKeown-Eyssen, R. W. Summers, R. I. Rothstein, C. A. Burke, et al. (2007)
JAMA 297, 2351-2359
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Dietary Folate Intake in Combination with MTHFR C677T Genotype and Promoter Methylation of Tumor Suppressor and DNA Repair Genes in Sporadic Colorectal Adenomas.

M. van den Donk, M. van Engeland, L. Pellis, B. J.M. Witteman, F. J. Kok, J. Keijer, and E. Kampman (2007)
Cancer Epidemiol. Biomarkers Prev. 16, 327-333
 |  Abstract »  |  Full Text »  |  PDF »

Colorectal cancer: a model for epigenetic tumorigenesis.

J J L Wong, N J Hawkins, and R L Ward (2007)
Gut 56, 140-148
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Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT).

F. S. Alyaqoub, L. Tao, P. M. Kramer, V. E. Steele, R. A. Lubet, W. T. Gunning, and M. A. Pereira (2007)
Carcinogenesis 28, 124-129
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Maspin: The New Frontier.

Z. Khalkhali-Ellis (2006)
Clin. Cancer Res. 12, 7279-7283
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Prevention of mouse lung tumors and modulation of DNA methylation by combined treatment with budesonide and R115777 (ZarnestraMT).

F. S. Alyaqoub, L. Tao, P. M. Kramer, V. E. Steele, R. A. Lubet, W. T. Gunning, and M. A. Pereira (2006)
Carcinogenesis 27, 2442-2447
 |  Abstract »  |  Full Text »  |  PDF »

Global DNA and p53 Region-Specific Hypomethylation in Human Colonic Cells Is Induced by Folate Depletion and Reversed by Folate Supplementation.

G. R. Wasson, A. P. McGlynn, H. McNulty, S. L. O'Reilly, V. J. McKelvey-Martin, G. McKerr, J. J. Strain, J. Scott, and C. S. Downes (2006)
J. Nutr. 136, 2748-2753
 |  Abstract »  |  Full Text »  |  PDF »

Chromosomal Instability Correlates with Genome-wide DNA Demethylation in Human Primary Colorectal Cancers..

J. Rodriguez, J. Frigola, E. Vendrell, R.-A. Risques, M. F. Fraga, C. Morales, V. Moreno, M. Esteller, G. Capella, M. Ribas, et al. (2006)
Cancer Res. 66, 8462-9468
 |  Abstract »  |  Full Text »  |  PDF »

Influence of human genetic variation on nutritional requirements.

P. J Stover (2006)
Am. J. Clinical Nutrition 83, 436S-442S
 |  Abstract »  |  Full Text »  |  PDF »

Large-scale structure of genomic methylation patterns.

R. A. Rollins, F. Haghighi, J. R. Edwards, R. Das, M. Q. Zhang, J. Ju, and T. H. Bestor (2006)
Genome Res. 16, 157-163
 |  Abstract »  |  Full Text »  |  PDF »

Genetic and Epigenetic Interactions between Folate and Aging in Carcinogenesis.

H. Jang, J. B. Mason, and S.-W. Choi (2005)
J. Nutr. 135, 2967S-2971S
 |  Abstract »  |  Full Text »  |  PDF »

Overlapping Gene Expression in Fetal Mouse Intestine Development and Human Colorectal Cancer.

M. Hu and R. A. Shivdasani (2005)
Cancer Res. 65, 8715-8722
 |  Abstract »  |  Full Text »  |  PDF »

The MTHFR C677T Polymorphism and Colorectal Cancer: The Multiethnic Cohort Study.

L. Le Marchand, L. R. Wilkens, L. N. Kolonel, and B. E. Henderson (2005)
Cancer Epidemiol. Biomarkers Prev. 14, 1198-1203
 |  Abstract »  |  Full Text »  |  PDF »

Reversal of DNA hypomethylation by folic acid supplements: possible role in colorectal cancer prevention.

J C Mathers (2005)
Gut 54, 579-581
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Effect of folic acid supplementation on genomic DNA methylation in patients with colorectal adenoma.

M Pufulete, R Al-Ghnaniem, A Khushal, P Appleby, N Harris, S Gout, P W Emery, and T A B Sanders (2005)
Gut 54, 648-653
 |  Abstract »  |  Full Text »  |  PDF »

Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer.

J. Frigola, X. Sole, M. F. Paz, V. Moreno, M. Esteller, G. Capella, and M. A. Peinado (2005)
Hum. Mol. Genet. 14, 319-326
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Epigenetics and cancer.

A. H. Lund and M. van Lohuizen (2004)
Genes & Dev. 18, 2315-2335
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Modulation by celecoxib and difluoromethylornithine of the methylation of DNA and the estrogen receptor-{alpha} gene in rat colon tumors.

M. A. Pereira, L. Tao, W. Wang, Y. Li, A. Umar, V. E. Steele, and R. A. Lubet (2004)
Carcinogenesis 25, 1917-1923
 |  Abstract »  |  Full Text »  |  PDF »

Vitamin B-12 Deficiency Induces Anomalies of Base Substitution and Methylation in the DNA of Rat Colonic Epithelium.

S.-W. Choi, S. Friso, H. Ghandour, P. J. Bagley, J. Selhub, and J. B. Mason (2004)
J. Nutr. 134, 750-755
 |  Abstract »  |  Full Text »  |  PDF »

Demethylation of the Synuclein {gamma} Gene CpG Island in Primary Gastric Cancers and Gastric Cancer Cell Lines.

N. Yanagawa, G. Tamura, T. Honda, M. Endoh, S. Nishizuka, and T. Motoyama (2004)
Clin. Cancer Res. 10, 2447-2451
 |  Abstract »  |  Full Text »  |  PDF »

Aberrant expression of the MEL1S gene identified in association with hypomethylation in adult T-cell leukemia cells.

M. Yoshida, K. Nosaka, J.-i. Yasunaga, I. Nishikata, K. Morishita, and M. Matsuoka (2004)
Blood 103, 2753-2760
 |  Abstract »  |  Full Text »  |  PDF »

Influence of in vitro manipulation on the stability of methylation patterns in the Snurf/Snrpn-imprinting region in mouse embryonic stem cells.

A. Schumacher and W. Doerfler (2004)
Nucleic Acids Res. 32, 1566-1576
 |  Abstract »  |  Full Text »  |  PDF »

The Epigenome as a Target for Cancer Chemoprevention.

L. Kopelovich, J. A. Crowell, and J. R. Fay (2003)
J Natl Cancer Inst 95, 1747-1757
 |  Abstract »  |  Full Text »  |  PDF »

Genes and Transposons Are Differentially Methylated in Plants, but Not in Mammals.

P. D. Rabinowicz, L. E. Palmer, B. P. May, M. T. Hemann, S. W. Lowe, W. R. McCombie, and R. A. Martienssen (2003)
Genome Res. 13, 2658-2664
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Gene Silencing in Cancer in Association with Promoter Hypermethylation.

J. G. Herman and S. B. Baylin (2003)
N. Engl. J. Med. 349, 2042-2054
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Association between Low Dietary Folate Intake and Suboptimal Cellular DNA Repair Capacity.

Q. Wei, H. Shen, L.-E Wang, C. M. Duphorne, P. C. Pillow, Z. Guo, Y. Qiao, and M. R. Spitz (2003)
Cancer Epidemiol. Biomarkers Prev. 12, 963-969
 |  Abstract »  |  Full Text »  |  PDF »

DNA Methylation, Smooth Muscle Cells, and Atherogenesis.

M. O. Hiltunen and S. Yla-Herttuala (2003)
Arterioscler. Thromb. Vasc. Biol. 23, 1750-1753
 |  Abstract »  |  Full Text »  |  PDF »

Dietary Folate and Selenium Affect Dimethylhydrazine-Induced Aberrant Crypt Formation, Global DNA Methylation and One-Carbon Metabolism in Rats.

C. D. Davis and E. O. Uthus (2003)
J. Nutr. 133, 2907-2914
 |  Abstract »  |  Full Text »  |  PDF »

Frequent Hypomethylation of Multiple Genes Overexpressed in Pancreatic Ductal Adenocarcinoma.

N. Sato, A. Maitra, N. Fukushima, N. T. van Heek, H. Matsubayashi, C. A. Iacobuzio-Donahue, C. Rosty, and M. Goggins (2003)
Cancer Res. 63, 4158-4166
 |  Abstract »  |  Full Text »  |  PDF »

Methylation status of uPA promoter as a molecular mechanism regulating prostate cancer invasion and growth in vitro and in vivo.

P. PAKNESHAN, R. H. XING, and S. A. RABBANI (2003)
FASEB J 17, 1081-1088
 |  Abstract »  |  Full Text »  |  PDF »

Frequent HOXA11 and THBS2 Promoter Methylation, and a Methylator Phenotype in Endometrial Adenocarcinoma.

B. P. Whitcomb, D. G. Mutch, T. J. Herzog, J. S. Rader, R. K. Gibb, and P. J. Goodfellow (2003)
Clin. Cancer Res. 9, 2277-2287
 |  Abstract »  |  Full Text »  |  PDF »

Glucose Metabolism in Cancer. EVIDENCE THAT DEMETHYLATION EVENTS PLAY A ROLE IN ACTIVATING TYPE II HEXOKINASE GENE EXPRESSION.

A. Goel, S. P. Mathupala, and P. L. Pedersen (2003)
J. Biol. Chem. 278, 15333-15340
 |  Abstract »  |  Full Text »  |  PDF »

Aberrant DNA Methylation: Have We Entered the Era of More Than One Type of Colorectal Cancer?.

B. Iacopetta (2003)
Am. J. Pathol. 162, 1043-1045
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The Relationship between Hypomethylation and CpG Island Methylation in Colorectal Neoplasia.

C. Bariol, C. Suter, K. Cheong, S.-L. Ku, A. Meagher, N. Hawkins, and R. Ward (2003)
Am. J. Pathol. 162, 1361-1371
 |  Abstract »  |  Full Text »  |  PDF »

DNA Ploidy and Markovian Analysis of Neoplastic Progression in Experimental Pancreatic Cancer.

R. G. Postier, M. R. Lerner, S. A. Lightfoot, R. Vannarath, M. M. Lane, J. S. Hanas, and D. J. Brackett (2003)
J. Histochem. Cytochem. 51, 303-309
 |  Abstract »  |  Full Text »  |  PDF »

Hypomethylation of the Synuclein{gamma} Gene CpG Island Promotes Its Aberrant Expression in Breast Carcinoma and Ovarian Carcinoma.

A. Gupta, A. K. Godwin, L. Vanderveer, A. Lu, and J. Liu (2003)
Cancer Res. 63, 664-673
 |  Abstract »  |  Full Text »  |  PDF »

DNA Methylation and Diet in Cancer ,.

G. L. Johanning, D. C. Heimburger, and C. J. Piyathilake (2002)
J. Nutr. 132, 3814S-3818
 |  Abstract »  |  Full Text »  |  PDF »

Low-penetrance Genes and Their Involvement in Colorectal Cancer Susceptibility.

M. M. de Jong, I. M. Nolte, G. J. te Meerman, W. T. A. van der Graaf, E. G. E. de Vries, R. H. Sijmons, R. M. W. Hofstra, and J. H. Kleibeuker (2002)
Cancer Epidemiol. Biomarkers Prev. 11, 1332-1352
 |  Abstract »  |  Full Text »  |  PDF »

Effect of folate supplementation on mucosal cell proliferation in high risk patients for colon cancer.

K Khosraviani, H P Weir, P Hamilton, J Moorehead, and K Williamson (2002)
Gut 51, 195-199
 |  Abstract »  |  Full Text »  |  PDF »

DNA Methyltransferase Deficiency Modifies Cancer Susceptibility in Mice Lacking DNA Mismatch Repair.

B. N. Trinh, T. I. Long, A. E. Nickel, D. Shibata, and P. W. Laird (2002)
Mol. Cell. Biol. 22, 2906-2917
 |  Abstract »  |  Full Text »  |  PDF »

Methylome profiling of cancer cells by amplification of inter-methylated sites (AIMS).

J. Frigola, M. Ribas, R.-A. Risques, and M. A. Peinado (2002)
Nucleic Acids Res. 30, e28
 |  Abstract »  |  Full Text »  |  PDF »

Methylation Matters: Modeling a Manageable Genome.

J. M. Ordway and T. Curran (2002)
Cell Growth Differ. 13, 149-162
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The Influence of Folate and Multivitamin Use on the Familial Risk of Colon Cancer in Women.

C. S. Fuchs, W. C. Willett, G. A. Colditz, D. J. Hunter, M. J. Stampfer, F. E. Speizer, and E. L. Giovannucci (2002)
Cancer Epidemiol. Biomarkers Prev. 11, 227-234
 |  Abstract »  |  Full Text »  |  PDF »

DNA hypomethylation and methyltransferase expression in atherosclerotic lesions.

M. O Hiltunen, M. P Turunen, T. P Hakkinen, J. Rutanen, M. Hedman, K. Makinen, A.-M. Turunen, K. Aalto-Setala, and S. Yla-Herttuala (2002)
Vascular Medicine 7, 5-11
 |  Abstract »  |  PDF »

Studies of methionine cycle intermediates (SAM, SAH), DNA methylation and the impact of folate deficiency on tumor numbers in Min mice.

S. Sibani, S. Melnyk, I. P. Pogribny, W. Wang, F. Hiou-Tim, L. Deng, J. Trasler, S.J. James, and R. Rozen (2002)
Carcinogenesis 23, 61-65
 |  Abstract »  |  Full Text »  |  PDF »

Promoter Hypermethylation of Multiple Genes in Nasopharyngeal Carcinoma.

J. Kwong, K.-W. Lo, K.-F. To, P. M. L. Teo, P. J. Johnson, and D. P. Huang (2002)
Clin. Cancer Res. 8, 131-137
 |  Abstract »  |  Full Text »  |  PDF »

DNA methylation patterns in hereditary human cancers mimic sporadic tumorigenesis.

M. Esteller, M. F. Fraga, M. Guo, J. Garcia-Foncillas, I. Hedenfalk, A. K. Godwin, J. Trojan, C. Vaurs-Barriere, Y.-J. Bignon, S. Ramus, et al. (2001)
Hum. Mol. Genet. 10, 3001-3007
 |  Abstract »  |  Full Text »  |  PDF »

Cables Enhances Cdk2 Tyrosine 15 Phosphorylation by Wee1, Inhibits Cell Growth, and Is Lost in Many Human Colon and Squamous Cancers.

C.-L. Wu, S. D. Kirley, H. Xiao, Y. Chuang, D. C. Chung, and L. R. Zukerberg (2001)
Cancer Res. 61, 7325-7332
 |  Abstract »  |  Full Text »  |  PDF »

Promoter Hypermethylation of Multiple Genes in Carcinoma of the Uterine Cervix.

S. M. Dong, H.-S. Kim, S.-H. Rha, and D. Sidransky (2001)
Clin. Cancer Res. 7, 1982-1986
 |  Abstract »  |  Full Text »  |  PDF »

Evaluation of global DNA hypomethylation in human colon cancer tissues by immunohistochemistry and image analysis.

F J Hernandez-Blazquez, M Habib, J-M Dumollard, C Barthelemy, M Benchaib, A de Capoa, and A Niveleau (2000)
Gut 47, 689-693
 |  Abstract »  |  Full Text »  |  PDF »

Chemopreventive Effects of Dietary Folate on Intestinal Polyps in Apc+/- Msh2-/- Mice.

J. Song, K.-J. Sohn, A. Medline, C. Ash, S. Gallinger, and Y.-I. Kim (2000)
Cancer Res. 60, 3191-3199
 |  Abstract »  |  Full Text »

Development and initial characterization of several new inbred strains of SENCAR mice for studies of multistage skin carcinogenesis.

L. G. Coghlan, I. Gimenez-Conti, H. E. Kleiner, S. M. Fischer, J. E. Rundhaug, C. J. Conti, T. J. Slaga, and J. DiGiovanni (2000)
Carcinogenesis 21, 641-646
 |  Abstract »  |  Full Text »  |  PDF »

Hypermethylation of Multiple Genes in Pancreatic Adenocarcinoma.

T. Ueki, M. Toyota, T. Sohn, C. J. Yeo, J.-P. J. Issa, R. H. Hruban, and M. Goggins (2000)
Cancer Res. 60, 1835-1839
 |  Abstract »  |  Full Text »

DNA methylation: past, present and future directions.

K. D. Robertson and P. A.Jones (2000)
Carcinogenesis 21, 461-467
 |  Abstract »  |  Full Text »  |  PDF »

Insights into the molecular pathogenesis of atherosclerosis and therapeutic strategies using gene transfer.

M. O Hiltunen, M. P Turunen, M. Laitinen, and S. Yla-Herttuala (2000)
Vascular Medicine 5, 41-48
 |  Abstract »  |  PDF »

Aberrant Methylation in Gastric Cancer Associated with the CpG Island Methylator Phenotype.

M. Toyota, N. Ahuja, H. Suzuki, F. Itoh, M. Ohe-Toyota, K. Imai, S. B. Baylin, and J.-P. J. Issa (1999)
Cancer Res. 59, 5438-5442
 |  Abstract »  |  Full Text »  |  PDF »

hMLH1 Promoter Hypermethylation in Microsatellite Instability-Positive Endometrial Carcinoma : Cause or Consequence?.

L. H. Ellenson (1999)
Am. J. Pathol. 155, 1399-1402
 |  Full Text »  |  PDF »

Risk Factors for Ki-ras Protooncogene Mutation in Sporadic Colorectal Adenomas.

M. E. Martinez, T. Maltzman, J. R. Marshall, J. Einspahr, M. E. Reid, R. Sampliner, D. J. Ahnen, S. R. Hamilton, and D. S. Alberts (1999)
Cancer Res. 59, 5181-5185
 |  Abstract »  |  Full Text »  |  PDF »

Abnormal Regulation of DNA Methyltransferase Expression during Colorectal Carcinogenesis.

A. M. De Marzo, V. L. Marchi, E. S. Yang, R. Veeraswamy, X. Lin, and W. G. Nelson (1999)
Cancer Res. 59, 3855-3860
 |  Abstract »  |  Full Text »  |  PDF »

Methylenetetrahydrofolate Reductase, Diet, and Risk of Colon Cancer.

M. L. Slattery, J. D. Potter, W. Samowitz, D. Schaffer, and M. Leppert (1999)
Cancer Epidemiol. Biomarkers Prev. 8, 513-518
 |  Abstract »  |  Full Text »

MTHFR Polymorphism, Methyl-Replete Diets and the Risk of Colorectal Carcinoma and Adenoma among U.S. Men and Women: An Example of Gene-Environment Interactions in Colorectal Tumorigenesis.

J. Chen, E. L. Giovannucci, and D. J. Hunter (1999)
J. Nutr. 129, 560
 |  Abstract »  |  Full Text »  |  PDF »

Infection with Human Immunodeficiency Virus Type 1 Upregulates DNA Methyltransferase, Resulting in De Novo Methylation of the Gamma Interferon (IFN-gamma ) Promoter and Subsequent Downregulation of IFN-gamma Production.

J. A. Mikovits, H. A. Young, P. Vertino, J.-P. J. Issa, P. M. Pitha, S. Turcoski-Corrales, D. D. Taub, C. L. Petrow, S. B. Baylin, and F. W. Ruscetti (1998)
Mol. Cell. Biol. 18, 5166-5177
 |  Abstract »  |  Full Text »

Establishment of methylation-sensitive-representational difference analysis and isolation of hypo- and hypermethylated genomic fragments in mouse liver tumors.

T. Ushijima, K. Morimura, Y. Hosoya, H. Okonogi, M. Tatematsu, T. Sugimura, and M. Nagao (1997)
PNAS 94, 2284-2289
 |  Abstract »  |  Full Text »  |  PDF »

DNA methylation and genetic instability in colorectal cancer cells.

C. Lengauer, K. W. Kinzler, and B. Vogelstein (1997)
PNAS 94, 2545-2550
 |  Abstract »  |  Full Text »  |  PDF »

Role of T Cell DNA Methylation in Lupus Syndromes.

R. L. Yung and B. C. Richardson (1994)
Lupus 3, 487-491
 |  Abstract »  |  PDF »

Concerted nonsyntenic allelic loss in human colorectal carcinoma.

D. Law, S Olschwang, J. Monpezat, D Lefrancois, D Jagelman, N. Petrelli, G Thomas, and A. Feinberg (1988)
Science 241, 961-965
 |  Abstract »  |  PDF »

Clonal analysis of human colorectal tumors.

E. Fearon, Hamilton SR, and B Vogelstein (1987)
Science 238, 193-197
 |  Abstract »  |  PDF »

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