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Science 12 April 1985:
Vol. 228. no. 4696, pp. 184 - 187
DOI: 10.1126/science.2983431
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Articles

Science, Vol 228, Issue 4696, 184-187
Copyright © 1985 by American Association for the Advancement of Science

articles

A region of the Herpesvirus saimiri genome required for oncogenicity

RC Desrosiers, A Bakker, J Kamine, LA Falk, RD Hunt, and NW King

Herpesvirus saimiri naturally infects squirrel monkeys (Saimiri sciureus) without producing signs of disease; infection of other New World primates, however, results in a rapidly progressing, malignant, T-cell lymphoma. Results described in this report identify a region of the viral genome that is required for oncogenicity in owl monkeys (Aotus trivirgatus); this region is not required for replication of the virus. This is believed to be the first such genomic region identified in a herpesvirus system.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Herpesvirus Saimiri STP-A Oncoprotein Utilizes Src Family Protein Tyrosine Kinase and Tumor Necrosis Factor Receptor-Associated Factors To Elicit Cellular Signal Transduction.
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J. Virol. 81, 2663-2674
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Growth transformation of human T cells by herpesvirus saimiri requires multiple tip-lck interaction motifs..
E. Heck, U. Friedrich, M. U. Gack, D. Lengenfelder, M. Schmidt, I. Muller-Fleckenstein, B. Fleckenstein, A. Ensser, and B. Biesinger (2006)
J. Virol. 80, 9934-9942
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Functional Characterization of the Complement Control Protein Homolog of Herpesvirus Saimiri: ARG-118 IS CRITICAL FOR FACTOR I COFACTOR ACTIVITIES.
A. K. Singh, J. Mullick, J. Bernet, and A. Sahu (2006)
J. Biol. Chem. 281, 23119-23128
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Regulation of intracellular signalling by the terminal membrane proteins of members of the Gammaherpesvirinae..
M. M. Brinkmann and T. F. Schulz (2006)
J. Gen. Virol. 87, 1047-1074
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Tyrosine Phosphorylation of the Tio Oncoprotein Is Essential for Transformation of Primary Human T Cells.
J.-C. Albrecht, I. Muller-Fleckenstein, M. Schmidt, B. Fleckenstein, and B. Biesinger (2005)
J. Virol. 79, 10507-10513
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T-Cell Growth Transformation by Herpesvirus Saimiri Is Independent of STAT3 Activation.
E. Heck, D. Lengenfelder, M. Schmidt, I. Muller-Fleckenstein, B. Fleckenstein, B. Biesinger, and A. Ensser (2005)
J. Virol. 79, 5713-5720
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Herpesvirus Ateles Tio Can Replace Herpesvirus Saimiri StpC and Tip Oncoproteins in Growth Transformation of Monkey and Human T Cells.
J.-C. Albrecht, B. Biesinger, I. Muller-Fleckenstein, D. Lengenfelder, M. Schmidt, B. Fleckenstein, and A. Ensser (2004)
J. Virol. 78, 9814-9819
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Activation of Stat3 Transcription Factor by Herpesvirus Saimiri STP-A Oncoprotein.
Y.-H. Chung, N.-h. Cho, M. I. Garcia, S.-H. Lee, P. Feng, and J. U. Jung (2004)
J. Virol. 78, 6489-6497
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Modulation of T-Cell Receptor Signal Transduction by Herpesvirus Signaling Adaptor Protein.
S.-H. Lee, Y.-H. Chung, N.-H. Cho, Y. Gwack, P. Feng, and J. U. Jung (2004)
Mol. Cell. Biol. 24, 5369-5382
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Generation and precise modification of a herpesvirus saimiri bacterial artificial chromosome demonstrates that the terminal repeats are required for both virus production and episomal persistence.
R. E. White, M. A. Calderwood, and A. Whitehouse (2003)
J. Gen. Virol. 84, 3393-3403
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Distinct Roles of Cellular Lck and p80 Proteins in Herpesvirus Saimiri Tip Function on Lipid Rafts.
J. Park, N.-H. Cho, J.-K. Choi, P. Feng, J. Choe, and J. U. Jung (2003)
J. Virol. 77, 9041-9051
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The Collagen Repeat Sequence Is a Determinant of the Degree of Herpesvirus Saimiri STP Transforming Activity.
J.-K. Choi, S. Ishido, and J. U. Jung (2000)
J. Virol. 74, 8102-8110
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Human herpesvirus 8 infections in the Amsterdam Cohort Studies (1984-1997): Analysis of seroconversions to ORF65 and ORF73.
J. Goudsmit, N. Renwick, N. H. T. M. Dukers, R. A. Coutinho, S. Heisterkamp, M. Bakker, T. F. Schulz, M. Cornelissen, and G. J. Weverling (2000)
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Signaling Activities of Gammaherpesvirus Membrane Proteins.
B. Damania, J.-K. Choi, and J. U. Jung (2000)
J. Virol. 74, 1593-1601
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Primary Structure of the Herpesvirus Ateles Genome.
J.-C. Albrecht (2000)
J. Virol. 74, 1033-1037
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Activation of the Lck Tyrosine-protein Kinase by the Binding of the Tip Protein of Herpesvirus Saimiri in the Absence of Regulatory Tyrosine Phosphorylation.
D. A. Hartley, T. R. Hurley, J. S. Hardwick, T. C. Lund, P. G. Medveczky, and B. M. Sefton (1999)
J. Biol. Chem. 274, 20056-20059
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Herpesvirus Ateles Gene Product Tio Interacts with Nonreceptor Protein Tyrosine Kinases.
J.-C. Albrecht, U. Friedrich, C. Kardinal, J. Koehn, B. Fleckenstein, S. M. Feller, and B. Biesinger (1999)
J. Virol. 73, 4631-4639
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Role of Cellular Tumor Necrosis Factor Receptor-Associated Factors in NF-kappa B Activation and Lymphocyte Transformation by Herpesvirus Saimiri STP.
H. Lee, J.-K. Choi, M. Li, K. Kaye, E. Kieff, and J. U. Jung (1999)
J. Virol. 73, 3913-3919
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Three Distinct Regions of the Murine Gammaherpesvirus 68 Genome Are Transcriptionally Active in Latently Infected Mice.
H. W. Virgin IV, R. M. Presti, X.-Y. Li, C. Liu, and S. H. Speck (1999)
J. Virol. 73, 2321-2332
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A Role for Herpesvirus Saimiri orf14 in Transformation and Persistent Infection.
M. Duboise, J. Guo, S. Czajak, H. Lee, R. Veazey, R. C. Desrosiers, and J. U. Jung (1998)
J. Virol. 72, 6770-6776
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Substitution of ras for the Herpesvirus Saimiri STP Oncogene in Lymphocyte Transformation.
J. Guo, K. Williams, S. M. Duboise, L. Alexander, R. Veazey, and J. U. Jung (1998)
J. Virol. 72, 3698-3704
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Mutation of the Lck-Binding Motif of Tip Enhances Lymphoid Cell Activation by Herpesvirus Saimiri.
S. M. Duboise, H. Lee, J. Guo, J.-K. Choi, S. Czajak, M. Simon, R. C. Desrosiers, and J. U. Jung (1998)
J. Virol. 72, 2607-2614
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STP and Tip Are Essential for Herpesvirus Saimiri Oncogenicity.
S. M. Duboise, J. Guo, S. Czajak, R. C. Desrosiers, and J. U. Jung (1998)
J. Virol. 72, 1308-1313
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gamma -Interferon Produced by CD8+ T Cells Infiltrating Kaposi's Sarcoma Induces Spindle Cells With Angiogenic Phenotype and Synergy With Human Immunodeficiency Virus-1 Tat Protein: An Immune Response to Human Herpesvirus-8 Infection?.
V. Fiorelli, R. Gendelman, M. Caterina Sirianni, H.-K. Chang, S. Colombini, P. D. Markham, P. Monini, J. Sonnabend, A. Pintus, R. C. Gallo, et al. (1998)
Blood 91, 956-967
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AU-rich elements target small nuclear RNAs as well as mRNAs for rapid degradation.
X. C. Fan, V. E. Myer, and J. A. Steitz (1997)
Genes & Dev. 11, 2557-2568
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A gene for dihydrofolate reductase in a herpesvirus.
J. Trimble, S. Murthy, A Bakker, R Grassmann, and R. Desrosiers (1988)
Science 239, 1145-1147
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