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Science 5 April 1985:
Vol. 228. no. 4695, pp. 75 - 77
DOI: 10.1126/science.3883494
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Articles

Science, Vol 228, Issue 4695, 75-77
Copyright © 1985 by American Association for the Advancement of Science

articles

Evidence for a malarial parasite interaction site on the major transmembrane protein of the human erythrocyte

MJ Friedman, M Fukuda, and RA Laine

Soluble oligosaccharides derived from the surface of human erythrocytes were tested for their ability to competitively inhibit invasion of erythrocytes by Plasmodium falciparum, a malarial parasite. Invasion was most effectively inhibited by erythroglycan, a carbohydrate component of the band 3 transmembrane protein. The lactosamine chains of erythroglycan contributed much of the inhibitory activity. This indication of a primary parasite interaction site on band 3 supports a role for this protein in mediating the radical alterations of the erythrocyte cytoskeleton that accompany invasion.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Band 3 is a host receptor binding merozoite surface protein 1 during the Plasmodium falciparum invasion of erythrocytes.
V. K. Goel, X. Li, H. Chen, S.-C. Liu, A. H. Chishti, and S. S. Oh (2003)
PNAS 100, 5164-5169
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