Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 5 April 1985:
Vol. 228. no. 4695, pp. 26 - 30
DOI: 10.1126/science.3975631
Prev | Table of Contents | Next

Articles

Science, Vol 228, Issue 4695, 26-30
Copyright © 1985 by American Association for the Advancement of Science

articles

Reversal of oncogenesis by the expression of a major histocompatibility complex class I gene

K Tanaka, KJ Isselbacher, G Khoury, and G Jay

The classical transplantation antigens (the major histocompatibility complex class I antigens) play a key role in host defense against cells expressing foreign antigens. Several naturally occurring tumors and virally transformed cells show an overall suppression of these surface antigens. Since the class I molecules are required in the presentation of neoantigens on tumor cells to the cytotoxic T lymphocytes, their absence from the cell surface may lead to the escape of these tumors from immunosurveillance. To test this possibility, a functional class I gene was transfected into human adenovirus 12-transformed mouse cells that do not express detectable levels of class I antigens; the transformants were tested for expression of the transfected gene and for changes in oncogenicity. The expression of a single class I gene, introduced by DNA-mediated gene transfer into highly tumorigenic adenovirus 12-transformed cells, was sufficient to abrogate the oncogenicity of these cells. This finding has important implications for the regulation of the malignant phenotype in certain tumors and for the potential modulation of oncogenicity through derepression of the endogenous class I genes.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Prognostic Significance of Serum {beta}2 Microglobulin Levels in Acute Myeloid Leukemia and Prognostic Scores Predicting Survival: Analysis of 1,180 Patients.
A.-M. Tsimberidou, H. M. Kantarjian, S. Wen, S. O'Brien, J. Cortes, W. G. Wierda, C. Koller, S. Pierce, M. Brandt, E. J. Freireich, et al. (2008)
Clin. Cancer Res. 14, 721-730
   Abstract »    Full Text »    PDF »
A Nonclassical MHC Class I Molecule Restricts CTL-Mediated Rejection of a Syngeneic Melanoma Tumor.
E. Y. Chiang and I. Stroynowski (2004)
J. Immunol. 173, 4394-4401
   Abstract »    Full Text »    PDF »
Gene Transfer in Ovarian Cancer Cells: A Comparison between Retroviral and Lentiviral Vectors.
S. Indraccolo, W. Habeler, V. Tisato, L. Stievano, E. Piovan, V. Tosello, G. Esposito, R. Wagner, K. Uberla, L. Chieco-Bianchi, et al. (2002)
Cancer Res. 62, 6099-6107
   Abstract »    Full Text »    PDF »
Increased Tumorigenicity, but Unchanged Immunogenicity, of Transporter for Antigen Presentation 1-deficient Tumors.
Z. Qin, C. Harders, X. Cao, C. Huber, T. Blankenstein, and B. Seliger (2002)
Cancer Res. 62, 2856-2860
   Abstract »    Full Text »    PDF »
Phase II Study of Direct Intralesional Gene Transfer of Allovectin-7, an HLA-B7/{beta}2-Microglobulin DNA-Liposome Complex, in Patients with Metastatic Melanoma.
A. T. Stopeck, A. Jones, E. M. Hersh, J. A. Thompson, D. M. Finucane, J. C. Gutheil, and R. Gonzalez (2001)
Clin. Cancer Res. 7, 2285-2291
   Abstract »    Full Text »    PDF »
HLA-DR and {beta}2 microglobulin expression in medullary and atypical medullary carcinoma of the breast: histopathologically similar but biologically distinct entities.
M. Feinmesser, A. Sulkes, S. Morgenstern, J. Sulkes, S. Stern, and E. Okon (2000)
J. Clin. Pathol. 53, 286-291
   Abstract »    Full Text »    PDF »
Phase I Study of Direct Intralesional Gene Transfer of HLA-B7 into Metastatic Renal Carcinoma Lesions.
B. I. Rini, L. M. Selk, and N. J. Vogelzang (1999)
Clin. Cancer Res. 5, 2766-2772
   Abstract »    Full Text »    PDF »
Combination Gene Therapy with CD86 and the MHC Class II Transactivator in the Control of Lung Tumor Growth.
B. K. Martin, J. G. Frelinger, and J. P.-Y. Ting (1999)
J. Immunol. 162, 6663-6670
   Abstract »    Full Text »    PDF »
Reduced Phosphorylation of p50 Is Responsible for Diminished NF-kappa B Binding to the Major Histocompatibility Complex Class I Enhancer in Adenovirus Type 12-Transformed Cells.
D. B. Kushner and R. P. Ricciardi (1999)
Mol. Cell. Biol. 19, 2169-2179
   Abstract »    Full Text »    PDF »
Alloantigen Gene Therapy for Squamous Cell Carcinoma of the Head and Neck: Results of a Phase 1 Trial.
L. L. Gleich, J. L. Gluckman, S. Armstrong, P. W. Biddinger, M. A. Miller, K. Balakrishnan, K. M. Wilson, H. I. Saavedra, and P. J. Stambrook (1998)
Arch Otolaryngol Head Neck Surg 124, 1097-1104
   Abstract »    Full Text »    PDF »
IFN-{gamma} Priming Up-Regulates IFN-Stimulated Gene Factor 3 (ISGF3) Components, Augmenting Responsiveness of IFN-Resistant Melanoma Cells to Type I IFNs.
L. H. Wong, I. Hatzinisiriou, R. J. Devenish, and S. J. Ralph (1998)
J. Immunol. 160, 5475-5484
   Abstract »    Full Text »    PDF »
The Human Leukocyte Antigen A2 Interferon-stimulated Response Element Consensus Sequence Binds a Nuclear Factor Required for Constitutive Expression.
J. F. Waring, J. E. Radford, L. J. Burns, and G. D. Ginder (1995)
J. Biol. Chem. 270, 12276-12285
   Abstract »    Full Text »    PDF »
Cooperativity between an Upstream TATA-like Sequence and a CAA Repeated Element Mediates E1A-dependent Negative Repression of the H-2K^b Class I Gene.
X. Tang, H.-O. Li, O. Sakatsume, T. Ohta, H. Tsutsui, A. F. A. Smit, M. Horikoshi, P. Kourilsky, A. Israël, G. Gachelin, et al. (1995)
J. Biol. Chem. 270, 2327-2336
   Abstract »    Full Text »    PDF »
Role of bone marrow-derived cells in presenting MHC class I-restricted tumor antigens.
A. Huang, P Golumbek, M Ahmadzadeh, E Jaffee, D Pardoll, and H Levitsky (1994)
Science 264, 961-965
   Abstract »    PDF »
Molecular Genetic Interventions for Cancer.
G.J. Nabel, E.G. Nabel, Z. Yang, B.A. Fox, G.E. Plautz, X. Gao, L. Huang, S. Shu, D. Gordon, and A.E. Chang (1994)
Cold Spring Harb Symp Quant Biol 59, 699-707
   Abstract »    PDF »
Immunosurveillance of Virus-induced Tumors.
C.J.M. Melief, W.L.E. Vasmel, R. Offringa, E.J.A.M. Sijts, E.A. Matthews, P.J. Peters, R.H. Meloen, A.J. van der Eb, and W.M. Kast (1989)
Cold Spring Harb Symp Quant Biol 54, 597-603
   Abstract »    PDF »
A transgenic mouse model for human neurofibromatosis.
S. Hinrichs, M Nerenberg, R. Reynolds, G Khoury, and G Jay (1987)
Science 237, 1340-1343
   Abstract »    PDF »
Post-transcriptional control of class I MHC mRNA expression in adenovirus 12-transformed cells.
R. Vaessen, A Houweling, and A. van der Eb (1987)
Science 235, 1486-1488
   Abstract »    PDF »
Tumor Necrosis Factors: Gene Structure and Biological Activities.
D.V. Goeddel, B.B. Aggarwal, P.W. Gray, D.W. Leung, G.E. Nedwin, M.A. Palladino, J.S. Patton, D. Pennica, H.M. Shepard, B.J. Sugarman, et al. (1986)
Cold Spring Harb Symp Quant Biol 51, 597-609
   Abstract »    PDF »
Histocompatibility antigens on murine tumors.
R. Goodenow, J. Vogel, and R. Linsk (1985)
Science 230, 777-783
   Abstract »    PDF »
Identification of CCAAT Displacement Protein (CDP/cut) as a Locus-specific Repressor of Major Histocompatibility Complex Gene Expression in Human Tumor Cells.
S. R. Snyder, J. Wang, J. F. Waring, and G. D. Ginder (2001)
J. Biol. Chem. 276, 5323-5330
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)