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Science 29 March 1985:
Vol. 227. no. 4694, pp. 1601 - 1602
DOI: 10.1126/science.3975630
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Articles

Science, Vol 227, Issue 4694, 1601-1602
Copyright © 1985 by American Association for the Advancement of Science

articles

Plasma homovanillic acid concentration and the severity of schizophrenic illness

KL Davis, M Davidson, RC Mohs, KS Kendler, BM Davis, CA Johns, Y DeNigris, and TB Horvath

Concentrations of plasma homovanillic acid before treatment were highly correlated with global severity of illness in schizophrenic patients, both before and after treatment. In contrast, a fixed dose of haloperidol did not affect those concentrations. Thus, in patients with a diagnosis of schizophrenia, plasma homovanillic acid may reflect the severity of illness, but not be influenced by short-term pharmacological perturbations by neuroleptics.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
The Pathophysiology of Schizophrenia Disorders: Perspectives From the Spectrum.
L. J. Siever and K. L. Davis (2004)
Am J Psychiatry 161, 398-413
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Monoamine Neurotransmitter Interactions in Drug-Free and Neuroleptic-Treated Schizophrenics.
K. H. John, C. Jean, J. J. Bartko, A. R. Doran, P. E. Konicki, W. z. Potter, and D. Pickar (1993)
Arch Gen Psychiatry 50, 606-614
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Effects of Metabolic Perturbation on Plasma Homovanillic Acid in Schizophrenia: Relationship to Prefrontal Cortex Volume.
A. Breier, O. R. Davis, R. W. Buchanan, L. A. Moricle, and R. C. Munson (1993)
Arch Gen Psychiatry 50, 541-550
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Changes in Plasma Homovanillic Acid Concentrations in Schizophrenic Patients Following Neuroleptic Discontinuation.
M. Davidson, R. S. Kahn, P. Powchik, P. Warne, M. F. Losonczy, R. Kaminsky, S. Apter, S. Jaff, and K. L. Davis (1991)
Arch Gen Psychiatry 48, 73-76
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Cerebrospinal Fluid and Plasma Monoamine Metabolites and Their Relation to Psychosis: Implications for Regional Brain Dysfunction in Schizophrenia.
D. Pickar, A. Breier, J. K. Hsiao, A. R. Doran, O. M. Wolkowitz, C. N. Pato, P. E. Konicki, and W. Z. Potter (1990)
Arch Gen Psychiatry 47, 641-648
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Circadian Variation of Plasma Homovanillic Acid Levels Is Attentuated by Fluphenazine in Patients With Schizophrenia.
A. R. Doran, R. Labarca, O. M. Wolkowitz, A. Roy, P. Douillet, and D. Pickar (1990)
Arch Gen Psychiatry 47, 558-563
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Effects of Renal Clearance on Plasma Concentrations of Homovanillic Acid: Methodologic Cautions.
W. Z. Potter, J. K. Hsiao, and S. M. Goldman (1989)
Arch Gen Psychiatry 46, 558-562
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Plasma 3-Methoxy-4-Hydroxyphenylglycol Changes Associated With Clinical State and Schizophrenic Subtype.
G. N. Ko, D. C. Jimerson, R. J. Wyatt, and L. B. Bigelow (1988)
Arch Gen Psychiatry 45, 842-846
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Alprazolam Augmentation of the Antipsychotic Effects of Fluphenazine in Schizophrenic Patients: Preliminary Results.
O. M. Wolkowitz, A. Breier, A. Doran, J. Kelsoe, P. Lucas, S. M. Paul, and D. Pickar (1988)
Arch Gen Psychiatry 45, 664-671
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Dopamine Metabolism and Disposition in Schizophrenic Patients: Studies Using Debrisoquin.
J. W. Maas, S. A. Contreras, E. Seleshi, and C. L. Bowden (1988)
Arch Gen Psychiatry 45, 553-559
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A Comparison of Plasma Homovanillic Acid Concentrations in Schizophrenic Patients and Normal Controls.
M. Davidson and K. L. Davis (1988)
Arch Gen Psychiatry 45, 561-563
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Plasma Homovanillic Acid as a Predictor of Response to Neuroleptics.
R. Davila, E. Manero, M. Zumarraga, I. Andia, J. W. Schweitzer, and A. J. Friedhoff (1988)
Arch Gen Psychiatry 45, 564-567
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Plasma Monoamine Metabolites in Psychotic Disorders.
M. B. Bowers Jr (1988)
Arch Gen Psychiatry 45, 595-596
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Increase in Human Urine Homovanillic Acid Concentration After Neuroleptic Treatment Is the Same With or Without Debrisoquin Administration.
S. A. Contreras, J. W. Maas, E. Seleshi, and C. L. Bowden (1987)
Arch Gen Psychiatry 44, 1109-1110
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Elevation of Plasma Homovanillic Acid Level Can Be Detected Within Four Hours After Initiation of Haloperidol Treatment.
R. Davila, M. ZUMARRAGA, K. Perea, I. Andia, and A. J. Friedhoff (1987)
Arch Gen Psychiatry 44, 837-838
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Clinical and Biochemical Effects of Verapamil Administration to Schizophrenic Patients.
D. Pickar, O. M. Wolkowitz, A. R. Doran, R. Labarca, A. Roy, A. Breier, and P. K. Narang (1987)
Arch Gen Psychiatry 44, 113-118
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Short-term Haloperidol Administration Acutely Elevates Human Plasma Homovanillic Acid Concentration.
M. Davidson, A. B. Giordani, R. C. Mohs, T. B. Horvath, B. M. Davis, P. Powchik, and K. L. Davis (1987)
Arch Gen Psychiatry 44, 189-190
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Acute Psychosis and Plasma Catecholamine Metabolites.
M. B. Bowers Jr and M. E. Swigar (1987)
Arch Gen Psychiatry 44, 190
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Longitudinal Measurement of Plasma Homovanillic Acid Levels in Schizophrenic Patients: Correlation With Psychosis and Response to Neuroleptic Treatment.
D. Pickar, R. Labarca, A. R. Doran, O. M. Wolkowitz, A. Roy, A. Breier, M. Linnoila, and S. M. Paul (1986)
Arch Gen Psychiatry 43, 669-676
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