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Science 29 March 1985:
Vol. 227. no. 4694, pp. 1601 - 1602
DOI: 10.1126/science.3975630
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Articles

Science, Vol 227, Issue 4694, 1601-1602
Copyright © 1985 by American Association for the Advancement of Science

articles

Plasma homovanillic acid concentration and the severity of schizophrenic illness

KL Davis, M Davidson, RC Mohs, KS Kendler, BM Davis, CA Johns, Y DeNigris, and TB Horvath

Concentrations of plasma homovanillic acid before treatment were highly correlated with global severity of illness in schizophrenic patients, both before and after treatment. In contrast, a fixed dose of haloperidol did not affect those concentrations. Thus, in patients with a diagnosis of schizophrenia, plasma homovanillic acid may reflect the severity of illness, but not be influenced by short-term pharmacological perturbations by neuroleptics.


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Effects of Metabolic Perturbation on Plasma Homovanillic Acid in Schizophrenia: Relationship to Prefrontal Cortex Volume.
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A Comparison of Plasma Homovanillic Acid Concentrations in Schizophrenic Patients and Normal Controls.
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Plasma Homovanillic Acid as a Predictor of Response to Neuroleptics.
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S. A. Contreras, J. W. Maas, E. Seleshi, and C. L. Bowden (1987)
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Elevation of Plasma Homovanillic Acid Level Can Be Detected Within Four Hours After Initiation of Haloperidol Treatment.
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Short-term Haloperidol Administration Acutely Elevates Human Plasma Homovanillic Acid Concentration.
M. Davidson, A. B. Giordani, R. C. Mohs, T. B. Horvath, B. M. Davis, P. Powchik, and K. L. Davis (1987)
Arch Gen Psychiatry 44, 189-190
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Acute Psychosis and Plasma Catecholamine Metabolites.
M. B. Bowers Jr and M. E. Swigar (1987)
Arch Gen Psychiatry 44, 190
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Longitudinal Measurement of Plasma Homovanillic Acid Levels in Schizophrenic Patients: Correlation With Psychosis and Response to Neuroleptic Treatment.
D. Pickar, R. Labarca, A. R. Doran, O. M. Wolkowitz, A. Roy, A. Breier, M. Linnoila, and S. M. Paul (1986)
Arch Gen Psychiatry 43, 669-676
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