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Science 29 March 1985:
Vol. 227. no. 4694, pp. 1544 - 1552
DOI: 10.1126/science.3975624
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Articles

Science, Vol 227, Issue 4694, 1544-1552
Copyright © 1985 by American Association for the Advancement of Science

articles

Promoting functional plasticity in the damaged nervous system

WJ Freed, L de Medinaceli, and RJ Wyatt

Damage to the central and peripheral nervous system often produces lasting functional deficits. A major focus of neuroscience research has been to enhance functional restitution of the damaged nervous system and thereby produce recovery of behavioral or physiological processes. Promising procedures include surgical, physical, and chemical manipulations to reduce scar formation and minimize the disruption of support elements, administration of growth-stimulating substances, tissue grafts to bridge gaps in fiber pathways, and embryonic brain tissue grafts to provide new cells with the potential to generate fiber systems. Two elements are required for functional nervous system repair: (i) neurons with the capacity to extend processes must be present, and (ii) the regenerating neurites must find a continuous, unbroken pathway to appropriate targets through a supportive milieu.


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Body Weight Support Treadmill Gait Training in the Subacute Recovery Phase of Incomplete Spinal Cord Injury.
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Neurorehabil Neural Repair 12, 119-136
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Regeneration of a Central Synapse Restores Nonassociative Learning.
B. K. Modney, C. L. Sahley, and K. J. Muller (1997)
J. Neurosci. 17, 6478-6482
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Models of Delayed Recovery.
A. Leviton, D. Bellinger, M. Pagano, and M. Rabinowitz (1995)
J Child Neurol 10, 385-391
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Plasticity of hippocampal circuitry in Alzheimer's disease.
J. Geddes, D. Monaghan, C. Cotman, I. Lott, R. Kim, and H. Chui (1985)
Science 230, 1179-1181
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