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Science 22 March 1985:
Vol. 227. no. 4693, pp. 1494 - 1496
DOI: 10.1126/science.3975623
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Articles

Science, Vol 227, Issue 4693, 1494-1496
Copyright © 1985 by American Association for the Advancement of Science

articles

Regional myocardial substrate uptake in hypertensive rats: a quantitative autoradiographic measurement

Y Yonekura, AB Brill, P Som, K Yamamoto, SC Srivastava, J Iwai, DR Elmaleh, E Livni, HW Strauss, MM Goodman, and al. et

Severe hypertension causes global and regional changes in myocardial perfusion and substrate utilization. Regional perfusion and fatty acid utilization were evaluated by dual-tracer autoradiography in normotensive and hypertensive rats of the Dahl strain. The regional distributions of perfusion and fatty acid utilization were homogeneous in normotensive rats. Severe hypertension was associated with a homogeneous pattern of regional perfusion, but fatty acid utilization was focally decreased in the free wall of the left ventricle. The decrease in fatty acid uptake was associated with a concomitant increase in glucose utilization. These findings suggest that severe hypertension is associated with uniform myocardial perfusion and focal alterations in the substrates used for the performance of myocardial work.


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