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Science 15 March 1985:
Vol. 227. no. 4692, pp. 1304 - 1308
DOI: 10.1126/science.3975615
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Articles

Science, Vol 227, Issue 4692, 1304-1308
Copyright © 1985 by American Association for the Advancement of Science

articles

Molecular models for DNA damaged by photoreaction

DA Pearlman, Holbrook SR, DH Pirkle, and SH Kim

Structural models of a DNA molecule containing a radiation-induced psoralen cross-link and of a DNA containing a thymine photodimer were constructed by applying energy-minimization techniques and model-building procedures to data from x-ray crystallographic studies. The helical axes of the models show substantial kinking and unwinding at the sites of the damage, which may have long-range as well as local effects arising from the concomitant changes in the supercoiling and overall structure of the DNA. The damaged areas may also serve as recognition sites for repair enzymes. These results should help in understanding the biologic effects of radiation-induced damage on cells.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Rapid repair of UVA-induced oxidized purines and persistence of UVB-induced dipyrimidine lesions determine the mutagenicity of sunlight in mouse cells.
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Accommodation and Repair of a UV Photoproduct in DNA at Different Rotational Settings on the Nucleosome Surface.
Z. M. Svedruzic, C. Wang, J. V. Kosmoski, and M. J. Smerdon (2005)
J. Biol. Chem. 280, 40051-40057
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Crystal structure of a DNA decamer containing a cis-syn thymine dimer.
H. Park, K. Zhang, Y. Ren, S. Nadji, N. Sinha, J.-S. Taylor, and C. Kang (2002)
PNAS 99, 15965-15970
   Abstract »    Full Text »    PDF »
Spore Photoproduct (SP) Lyase from Bacillus subtilis Specifically Binds to and Cleaves SP (5-Thyminyl-5,6-Dihydrothymine) but Not Cyclobutane Pyrimidine Dimers in UV-Irradiated DNA.
T. A. Slieman, R. Rebeil, and W. L. Nicholson (2000)
J. Bacteriol. 182, 6412-6417
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Evidence for Dinucleotide Flipping by DNA Photolyase.
B. J. Vande Berg and G. B. Sancar (1998)
J. Biol. Chem. 273, 20276-20284
   Abstract »    Full Text »    PDF »
DNA damage can alter the stability of nucleosomes: Effects are dependent on damage type.
D. B. Mann, D. L. Springer, and M. J. Smerdon (1997)
PNAS 94, 2215-2220
   Abstract »    Full Text »    PDF »
Human DNA Topoisomerase I-mediated Cleavages Stimulated by Ultraviolet Light-induced DNA Damage.
A. Lanza, S. Tornaletti, C. Rodolfo, M. C. Scanavini, and A. M. Pedrini (1996)
J. Biol. Chem. 271, 6978-6986
   Abstract »    Full Text »    PDF »
Probing the Conformation of Nucleosome Linker DNA in Situ with Pyrimidine Dimer Formation.
J. R. Pehrson and J. R. Pehrson (1995)
J. Biol. Chem. 270, 22440-22444
   Abstract »    Full Text »    PDF »
Crystal structure of DNA photolyase from Escherichia coli.
H. Park, S. Kim, A Sancar, and J Deisenhofer (1995)
Science 268, 1866-1872
   Abstract »    PDF »
Structure of a psoralen cross-linked DNA in solution by nuclear magnetic resonance.
M. Tomic, D. Wemmer, and S. Kim (1987)
Science 238, 1722-1725
   Abstract »    PDF »
Insecticide Resistance: Challenge to Pest Management and Basic Research.
L. B. BRATTSTEN, C. W. HOLYOKE JR., J. R. LEEPER, and K. F. RAFFA (1986)
Science 231, 1255-1260
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Science. ISSN 0036-8075 (print), 1095-9203 (online)