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Science 8 March 1985:
Vol. 227. no. 4691, pp. 1247 - 1249
DOI: 10.1126/science.3871966
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Articles

Science, Vol 227, Issue 4691, 1247-1249
Copyright © 1985 by American Association for the Advancement of Science

articles

Increased plasma interleukin-1 activity in women after ovulation

JG Cannon and CA Dinarello

The polypeptide interleukin-1 mediates many host responses to infection and inflammation. A method was developed for studying interleukin-1 levels in human plasma from febrile patients. Interleukin-1 activity was also consistently found in plasma samples from women in the luteal phase of their menstrual cycle. This activity was neutralized by a specific antiserum to human interleukin-1 and was low in plasma from healthy men and preovulatory women. Thus interleukin-1 appears to have a role in normal physiological conditions as well as in disease states.


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Science. ISSN 0036-8075 (print), 1095-9203 (online)