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Science 8 March 1985:
Vol. 227. no. 4691, pp. 1227 - 1228
DOI: 10.1126/science.2983419
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Articles

Science, Vol 227, Issue 4691, 1227-1228
Copyright © 1985 by American Association for the Advancement of Science

articles

Subcellular localization of the product of the long open reading frame of human T-cell leukemia virus type I

WC Goh, J Sodroski, C Rosen, M Essex, and WA Haseltine

Human T-cell leukemia virus type I (HTLV-I) is a retrovirus associated with adult T-cell leukemia and lymphoma. In addition to containing the gag, pol, and env genes of the chronic leukemia viruses, the genome of HTLV-I contains a long open reading frame (LOR) located between the 3' end of the envelope gene and the 3' long terminal repeat sequence (LTR). It has been suggested that a protein of 42 kilodaltons that is encoded by the LOR region may participate in both trans-acting transcriptional regulation of the viral LTR as well as in the transforming properties of HTLV-I. It is reported here that a significant fraction of the 42-kilodalton HTLV LOR product is located in the nucleus of HTLV-I-infected transformed lymphocytes, a finding that is consistent with its proposed functions.


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Trans-activator gene of human T-lymphotropic virus type III (HTLV-III).
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Location of the trans-activating region on the genome of human T-cell lymphotropic virus type III.
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Studies of the putative transforming protein of the type I human T-cell leukemia virus.
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J Sodroski, C Rosen, W. Goh, and W Haseltine (1985)
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Science. ISSN 0036-8075 (print), 1095-9203 (online)