Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 March 1985:
Vol. 227. no. 4690, pp. 1059 - 1061
DOI: 10.1126/science.3975602
Prev | Table of Contents | Next

Articles

Science, Vol 227, Issue 4690, 1059-1061
Copyright © 1985 by American Association for the Advancement of Science

articles

Regulation of extravascular coagulation by microvascular permeability

HF Dvorak, DR Senger, AM Dvorak, VS Harvey, and J McDonagh

Extravascular coagulation is a prominent feature of such important pathological processes as cellular immunity and neoplasia and has been thought to result from procoagulants associated with the inflammatory or tumor cells peculiar to these entities. It was found that increased microvascular permeability alone is sufficient to induce equivalent extravascular coagulation in several normal tissues. The results indicate that saturating levels of procoagulant are present even in normal tissues and that microvascular permeability is a rate-limiting step in extravascular coagulation.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Effects of VEGF and FGF2 on the Revascularization of Severed Human Dental Pulps.
E.M. Mullane, Z. Dong, C.M. Sedgley, J.C.-C. Hu, T.M. Botero, G.R. Holland, and J.E. Nor (2008)
Journal of Dental Research 87, 1144-1148
   Abstract »    Full Text »    PDF »
Effect of mini-tyrosyl-tRNA synthetase on ischemic angiogenesis, leukocyte recruitment, and vascular permeability.
G. Cheng, H. Zhang, X. Yang, E. Tzima, K. L. Ewalt, P. Schimmel, and J. E. Faber (2008)
Am J Physiol Regulatory Integrative Comp Physiol 295, R1138-R1146
   Abstract »    Full Text »    PDF »
Citrullinated Fibrinogen Inhibits Thrombin-catalysed Fibrin Polymerization.
M. Nakayama-Hamada, A. Suzuki, H. Furukawa, R. Yamada, and K. Yamamoto (2008)
J. Biochem. 144, 393-398
   Abstract »    Full Text »    PDF »
Caveolin-1-Deficient Mice Have Increased Tumor Microvascular Permeability, Angiogenesis, and Growth.
M. I. Lin, J. Yu, T. Murata, and W. C. Sessa (2007)
Cancer Res. 67, 2849-2856
   Abstract »    Full Text »    PDF »
Biomimetic amplification of nanoparticle homing to tumors.
D. Simberg, T. Duza, J. H. Park, M. Essler, J. Pilch, L. Zhang, A. M. Derfus, M. Yang, R. M. Hoffman, S. Bhatia, et al. (2007)
PNAS 104, 932-936
   Abstract »    Full Text »    PDF »
Peptides selected for binding to clotted plasma accumulate in tumor stroma and wounds.
J. Pilch, D. M. Brown, M. Komatsu, T. A. H. Jarvinen, M. Yang, D. Peters, R. M. Hoffman, and E. Ruoslahti (2006)
PNAS 103, 2800-2804
   Abstract »    Full Text »    PDF »
Hemostatic Regulators of Tumor Angiogenesis: A Source of Antiangiogenic Agents for Cancer Treatment?.
M. E. Daly, A. Makris, M. Reed, and C. E. Lewis (2003)
J Natl Cancer Inst 95, 1660-1673
   Abstract »    Full Text »    PDF »
How Tumors Make Bad Blood Vessels and Stroma.
H. F. Dvorak (2003)
Am. J. Pathol. 162, 1747-1757
   Full Text »    PDF »
Vascular Permeability Factor/Vascular Endothelial Growth Factor: A Critical Cytokine in Tumor Angiogenesis and a Potential Target for Diagnosis and Therapy.
H. F. Dvorak (2002)
J. Clin. Oncol. 20, 4368-4380
   Abstract »    Full Text »    PDF »
Coordinate Expression of Anticoagulant Heparan Sulfate Proteoglycans and Serine Protease Inhibitors in the Rat Ovary: A Potent System of Proteolysis Control.
S. Hasan, G. Hosseini, M. Princivalle, J.-C. Dong, D. Birsan, C. Cagide, and A. I. de Agostini (2002)
Biol Reprod 66, 144-158
   Abstract »    Full Text »
Fibrinogen Stimulates Macrophage Chemokine Secretion Through Toll-Like Receptor 4.
S. T. Smiley, J. A. King, and W. W. Hancock (2001)
J. Immunol. 167, 2887-2894
   Abstract »    Full Text »    PDF »
Angiogenesis Therapy : Amidst the Hype, the Neglected Potential for Serious Side Effects.
S. E. Epstein, R. Kornowski, S. Fuchs, and H. F. Dvorak (2001)
Circulation 104, 115-119
   Full Text »    PDF »
Effect of thrombin inhibition on synovial inflammation in antigen induced arthritis.
P. A. Varisco, V. Péclat, K. van Ness, A. Bischof-Delaloye, A. So, and N. Busso (2000)
Ann Rheum Dis 59, 781-787
   Abstract »    Full Text »
VEGF Expression by Epithelial and Stromal Cell Compartments : Resolving a Controversy.
D. R. Senger and L. Van De Water (2000)
Am. J. Pathol. 157, 1-3
   Full Text »    PDF »
Platelet and Coagulation Activation with Vascular Endothelial Growth Factor Generation in Soft Tissue Sarcomas.
H. M. W. Verheul, K. Hoekman, F. Lupu, H. J. Broxterman, P. van der Valk, A. K. Kakkar, and H. M. Pinedo (2000)
Clin. Cancer Res. 6, 166-171
   Abstract »    Full Text »
Congenital Hemorrhagic Disorders: New Insights into the Pathophysiology and Treatment of Hemophilia.
U. Hedner, D. Ginsburg, J. M. Lusher, and K. A. High (2000)
Hematology 2000, 241-265
   Abstract »    Full Text »    PDF »
Fibrin Fragment Induction of Plasminogen Activator Inhibitor Transcription Is Mediated by Activator Protein-1 Through a Highly Conserved Element.
M. A. Olman, J. S. Hagood, W. L. Simmons, G. M. Fuller, C. Vinson, and K. E. White (1999)
Blood 94, 2029-2038
   Abstract »    Full Text »    PDF »
Hemostatic factors in rabbit limb lymph: relationship to mechanisms regulating extravascular coagulation.
D. T. Le, P. Borgs, T. W. Toneff, M. H. Witte, and S. I. Rapaport (1998)
Am J Physiol Heart Circ Physiol 274, H769-H776
   Abstract »    Full Text »    PDF »
Urokinase in rheumatoid arthritis: causal or coincidental?.
N. BUSSO and A. SO (1997)
Ann Rheum Dis 56, 705-706
   Full Text »    PDF »
Tissue Factor Expression in Mesothelial Cells: Induction Both In Vivo and In Vitro.
K. D. Bottles, Z. Laszik, J. H. Morrissey, and G. T. Kinasewitz (1997)
Am. J. Respir. Cell Mol. Biol. 17, 164-172
   Abstract »    Full Text »
Characterization and Hormonal Modulation of Anticoagulant Heparan Sulfate Proteoglycans Synthesized by Rat Ovarian Granulosa Cells.
G. Hosseini, J. Liu, and A. I.d. Agostini (1996)
J. Biol. Chem. 271, 22090-22099
   Abstract »    Full Text »    PDF »
Delayed Pressure Urticaria Histologically Resembles Cutaneous Late-Phase Reactions.
Y. A. Mekori, B. S. Dobozin, A. L. Schocket, P. F. Kohler, and R. A. F. Clark (1988)
Arch Dermatol 124, 230-235
   Abstract »    PDF »
Protein Binding of Macromolecular Anticancer Agent SMANCS: Characterization of Poly(styrene-co-maleic acid) Derivatives as an Albumin Binding Ligand.
A. Kobayashi, T. Oda, and H. Maeda (1988)
Journal of Bioactive and Compatible Polymers 3, 319-333
   Abstract »    PDF »
Surface-dependent Coagulation Enzymes. FLOW KINETICS OF FACTOR Xa GENERATION ON LIVE CELL MEMBRANES.
M. P. McGee and T. Chou (2001)
J. Biol. Chem. 276, 7827-7835
   Abstract »    Full Text »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)