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Science 1 March 1985:
Vol. 227. no. 4690, pp. 1044 - 1047
DOI: 10.1126/science.3919442
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Articles

Science, Vol 227, Issue 4690, 1044-1047
Copyright © 1985 by American Association for the Advancement of Science

articles

Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms

CM Croce, M Isobe, A Palumbo, J Puck, J Ming, D Tweardy, J Erikson, M Davis, and G Rovera

A human complementary DNA clone specific for the alpha-chain of the T-cell receptor and a panel of rodent X human somatic cell hybrids were used to map the alpha-chain gene to human chromosome 14 in a region proximal to the immunoglobulin heavy chain locus. Analysis by means of in situ hybridization of human metaphase chromosomes served to further localize the alpha-chain gene to region 14q11q12, which is consistently involved in translocations and inversions detectable in human T-cell leukemias and lymphomas. Thus, the locus for the alpha-chain T-cell receptor may participate in oncogene activation in T-cell tumors.


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