Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Site Tools

  • AAAS
  • Subscribe
  • Feedback

Site Search

Search Advanced

Science 1 March 1985:
Vol. 227. no. 4690, pp. 1036 - 1038
DOI: 10.1126/science.2983417
Prev | Table of Contents | Next

Articles

Science, Vol 227, Issue 4690, 1036-1038
Copyright © 1985 by American Association for the Advancement of Science

articles

Evidence for exposure to HTLV-III in Uganda before 1973

WC Saxinger, PH Levine, AG Dean, G de The, G Lange-Wantzin, J Moghissi, F Laurent, M Hoh, MG Sarngadharan, and RC Gallo

Fifty of 75 serum samples collected in the West Nile district of Uganda between August 1972 and July 1973 contained antibodies reactive with human T-cell leukemia (lymphotropic) virus type 3 (HTLV-III; mean titer, 601), while 12 of 75 samples were positive in a similar test for HTLV type 1 (HTLV-1) antibodies (mean titer, 236). The samples were screened by enzyme-linked immunosorbent assay and positive results were confirmed by a newly developed unlabeled antibody-peroxidase procedure with enhanced sensitivity for detection of antibody binding to immunoblots of HTLV-III antigen, demonstrating antibodies to proteins with molecular weights of 24,000, 41,000, and 76,000 in nearly all positive samples. Analysis of titration data indicated enhanced titers of antibody against HTLV-III and HTLV-I when coinfection occurred. The high prevalence and relatively low titers [compared to serum from patients with acquired immune deficiency syndrome (AIDS)] of antibodies recognizing HTLV-III proteins in sera from this population at a time that may predate or coincide with the appearance or spread of the AIDS agent (HTLV-III) suggest that the virus detected may have been a predecessor of HTLV-III or is HTLV-III itself but existing in a population acclimated to its presence. It further suggests an African origin of HTLV-III.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Documentation of an AIDS Virus Infection in the United States in 1968.
R. F. Garry, M. H. Witte, A. A. Gottlieb, M. Elvin-Lewis, M. S. Gottlieb, C. L. Witte, S. S. Alexander, W. R. Cole, and W. L. Drake Jr (1988)
JAMA 260, 2085-2087
   Abstract »    PDF »
Transmission of Human Immunodeficiency Virus by Transplantation of a Renal Allograft, with Development of the Acquired Immunodeficiency Syndrome.
P. KUMAR, J. E. PEARSON, D. H. MARTIN, S. H. LEECH, P. D. BUISSERET, H. C. BEZBAK, F. M. GONZALEZ, J. R. ROYER, H. Z. STREICHER, and W. C. SAXINGER (1987)
Ann Intern Med 106, 244-245
   Abstract »    PDF »
New human T-lymphotropic retrovirus related to simian T-lymphotropic virus type III (STLV-IIIAGM).
P. Kanki, F Barin, S M'Boup, J. Allan, J. Romet-Lemonne, R Marlink, M. McLane, T. Lee, B Arbeille, F Denis, et al. (1986)
Science 232, 238-243
   Abstract »    PDF »
Insect-Borne Transmission of AIDS.
M. J. Blaser (1986)
JAMA 255, 463-464
   Abstract »    PDF »
The Acquired Immunodeficiency Syndrome in Haiti.
J. W. PAPE, B. LIAUTAUD, F. THOMAS, J.-R. MATHURIN, M.-M. A. ST. AMAND, M. BONCY, V. PEAN, M. PAMPHILE, A. C. LAROCHE, J. DEHOVITZ, et al. (1985)
Ann Intern Med 103, 674-678
   Abstract »    PDF »
A Human T-Lymphotropic Retrovirus (HTLV-III) as the Cause of the Acquired Immunodeficiency Syndrome.
R. C. GALLO and F. WONG-STAAL (1985)
Ann Intern Med 103, 679-689
   Abstract »    PDF »
Lymphadenopathy-Associated Virus: From Molecular Biology to Pathogenicity.
L. MONTAGNIER (1985)
Ann Intern Med 103, 689-693
   Abstract »    PDF »
HTLV-III Infection Among Health Care Workers: Association With Needle-Stick Injuries.
S. H. Weiss, W. C. Saxinger, D. Rechtman, M. H. Grieco, J. Nadler, S. Holman, H. M. Ginzburg, J. E. Groopman, J. J. Goedert, P. D. Markham, et al. (1985)
JAMA 254, 2089-2093
   Abstract »    PDF »
The epidemiology of AIDS: current status and future prospects.
J. Curran, W. Morgan, A. Hardy, H. Jaffe, W. Darrow, and W. Dowdle (1985)
Science 229, 1352-1357
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)