Note to users. If you're seeing this message, it means that your browser cannot find this page's style/presentation instructions -- or possibly that you are using a browser that does not support current Web standards. Find out more about why this message is appearing, and what you can do to make your experience of our site the best it can be.

Science 22 February 1985:
Vol. 227. no. 4689, pp. 941 - 945
DOI: 10.1126/science.3918347
Prev | Table of Contents | Next

Articles

Science, Vol 227, Issue 4689, 941-945
Copyright © 1985 by American Association for the Advancement of Science

articles

Chromosomal locations of the murine T-cell receptor alpha-chain gene and the T-cell gamma gene

DM Kranz, H Saito, CM Disteche, K Swisshelm, D Pravtcheva, FH Ruddle, HN Eisen, and S Tonegawa

Two independent methods were used to identify the mouse chromosomes on which are located two families of immunoglobulin (Ig)-like genes that are rearranged and expressed in T lymphocytes. The genes coding for the alpha subunit of T-cell receptors are on chromosome 14 and the gamma genes, whose function is yet to be determined, are on chromosome 13. Since genes for the T-cell receptor beta chain were previously shown to be on mouse chromosome 6, all three of the Ig-like multigene families expressed and rearranged in T cells are located on different chromosomes, just as are the B-cell multigene families for the Ig heavy chain, and the Ig kappa and lambda light chains. The findings do not support earlier contentions that genes for T-cell receptors are linked to the Ig heavy chain locus (mouse chromosome 12) or to the major histocompatibility complex (mouse chromosome 17).


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Age-Dependent TCR Revision Mediated by Interaction between {alpha}beta TCR and Self-Antigens.
M. Takase, E. M. Kanagawa, and O. Kanagawa (2007)
J. Immunol. 179, 2163-2169
   Abstract »    Full Text »    PDF »
Aberrant recombination involving the granzyme locus occurs in Atm-/- T-cell lymphomas.
C. J. Winrow, D. G. Pankratz, C. R. T. Vibat, T.J. Bowen, M. A. Callahan, A. J. Warren, B. S. Hilbush, A. Wynshaw-Boris, K. W. Hasel, Z. Weaver, et al. (2005)
Hum. Mol. Genet. 14, 2671-2684
   Abstract »    Full Text »    PDF »
Synchronized rearrangement of T-cell gamma and beta chain genes in fetal thymocyte development.
W Born, G Rathbun, P Tucker, P Marrack, and J Kappler (1986)
Science 234, 479-482
   Abstract »    PDF »


To Advertise     Find Products

Science. ISSN 0036-8075 (print), 1095-9203 (online)