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Science 15 February 1985:
Vol. 227. no. 4688, pp. 761 - 763
DOI: 10.1126/science.3918346
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Articles

Science, Vol 227, Issue 4688, 761-763
Copyright © 1985 by American Association for the Advancement of Science

articles

Immunoprecipitation of insulin receptors from cultured human lymphocytes (IM-9 cells) by antibodies to pp60src

N Perrotti, SI Taylor, ND Richert, UR Rapp, IH Pastan, and J Roth

The family of tyrosine-specific protein kinases includes proteins encoded by retroviral oncogenes as well as receptors for insulin and several growth factors. Antibodies to pp60src, the protein encoded by the src oncogene of Rous sarcoma virus (RSV), can specifically immunoprecipitate affinity-labeled insulin receptors from cultured human lymphocytes (IM-9 cells). This precipitation is specifically inhibited by the src gene product purified from RSV-transformed rat cells. These observations provide evidence that there is structural homology between the insulin receptors and pp60src.




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Science. ISSN 0036-8075 (print), 1095-9203 (online)