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Science 15 February 1985:
Vol. 227. no. 4688, pp. 759 - 761
DOI: 10.1126/science.2982214
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Articles

Science, Vol 227, Issue 4688, 759-761
Copyright © 1985 by American Association for the Advancement of Science

articles

Distinct hepatic receptors for low density lipoprotein and apolipoprotein E in humans

JM Hoeg, SJ Demosky Jr, RE Gregg, EJ Schaefer, and HB Brewer Jr

Since the liver is a central organ for lipid and lipoprotein synthesis and catabolism, hepatic receptors for specific apolipoproteins on plasma lipoproteins would be expected to modulate lipid and lipoprotein metabolism. The role of hepatic receptors for low density lipoproteins and apolipoprotein E-containing lipoproteins was evaluated in patients with complementary disorders in lipoprotein metabolism: abetalipoproteinemia and homozygous familial hypercholesterolemia. In addition, hepatic membranes from a patient with familial hypercholesterolemia were studied and compared before and after portacaval shunt surgery. The results establish that the human liver has receptors for apolipoproteins B and E. Furthermore, in the human, hepatic receptors for low density lipoproteins and apolipoprotein E are genetically distinct and can undergo independent control.


THIS ARTICLE HAS BEEN CITED BY OTHER ARTICLES:
Chylomicron remnant uptake in the livers of mice expressing human apolipoproteins E3, E2 (Arg158->Cys), and E3-Leiden.
S.-J. Lee, I. Grosskopf, S. Y. Choi, and A. D. Cooper (2004)
J. Lipid Res. 45, 2199-2210
   Abstract »    Full Text »    PDF »
Familial Hypercholesterolemia: What the Zebra Can Teach Us About the Horse.
J. M. Hoeg (1994)
JAMA 271, 543-546
   Abstract »    PDF »


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