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Science 15 February 1985:
Vol. 227. no. 4688, pp. 749 - 751
DOI: 10.1126/science.2982212
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Articles

Science, Vol 227, Issue 4688, 749-751
Copyright © 1985 by American Association for the Advancement of Science

articles

Induction of DNA synthesis in cultured rat hepatocytes through stimulation of alpha 1 adrenoreceptor by norepinephrine

JL Cruise, KA Houck, and GK Michalopoulos

Addition of norepinephrine to primary cultures of adult rat hepatocytes stimulates the incorporation of [3H]thymidine in a dose-dependent manner. This effect has been observed in serum-free medium containing epidermal growth factor and insulin. Stimulation of DNA synthesis by norepinephrine was strongly antagonized by the alpha 1-adrenergic antagonist prazosin but not by an alpha 2 antagonist or by a beta-adrenergic blocker. The beta agonist isoproterenol did not stimulate significant DNA synthesis. These results indicate that catecholamines interact with the alpha 1 adrenoreceptor to stimulate DNA synthesis in hepatocytes. Since alpha 1 receptors are present in most cells, this receptor may be important in cell growth regulation.


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alpha 1-Adrenergic Receptor Subtypes Differentially Control the Cell Cycle of Transfected CHO Cells through a cAMP-dependent Mechanism Involving p27Kip1.
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Effect of Cyclosporine A on Hepatic Compensatory Growth: Role of Calcium Status.
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Smad7 Is Induced by Norepinephrine and Protects Rat Hepatocytes from Activin A-induced Growth Inhibition.
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alpha 1 Adrenergic Agonist Induction of p21waf1/cip1 mRNA Stability in Transfected HepG2 Cells Correlates with the Increased Binding of an AU-rich Element Binding Factor.
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Cross-talk between alpha 1B-Adrenergic Receptor (alpha 1BAR) and Interleukin-6 (IL-6) Signaling Pathways. ACTIVATION OF alpha 1BAR INHIBITS IL-6-ACTIVATED STAT3 IN HEPATIC CELLS BY A p42/44 MITOGEN-ACTIVATED PROTEIN KINASE-DEPENDENT MECHANISM.
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Cell-Cell Signaling in Early Cortical Development.
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Neuroscientist 1, 268-276
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Decrease in nuclear phospholipids associated with DNA replication.
N. Maraldi, S Santi, N Zini, A Ognibene, R Rizzoli, G Mazzotti, R Di Primio, R Bareggi, V Bertagnolo, C Pagliarini, et al. (1993)
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Mechanisms of Rodent Liver Carcinogenesis.
G. K. Michalopoulos, P. M. Eckl, J. L. Cruise, D. L. Novicki, and R. L. Jirtle (1987)
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