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Science 15 February 1985:
Vol. 227. no. 4688, pp. 747 - 749
DOI: 10.1126/science.2982211
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Articles

Science, Vol 227, Issue 4688, 747-749
Copyright © 1985 by American Association for the Advancement of Science

articles

Oxidative autoactivation of latent collagenase by human neutrophils

SJ Weiss, G Peppin, X Ortiz, C Ragsdale, and ST Test

The pathological destruction of collagen plays a key role in the development of inflammatory disease states affecting every organ system in the human body. Neutrophils localized at inflammatory sites can potentially degrade collagen by releasing a metalloenzyme, collagenase, which is stored in a latent inactive form. Triggered human neutrophils were shown to release and simultaneously activate their latent collagenase. The activation of the latent enzyme was coupled to an oxidative process that required the generation of a highly reactive oxygen metabolite, hypochlorous acid. Oxidative regulation of latent collagenase activity may be important in the pathogenesis of connective tissue damage in vivo.


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