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Science 8 February 1985:
Vol. 227. no. 4687, pp. 640 - 642
DOI: 10.1126/science.3969553
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Articles
Science, Vol 227, Issue 4687, 640-642
Copyright © 1985 by American Association for the Advancement of Science
Flurbiprofen: a potent inhibitor of alveolar bone resorption in beagles
RC Williams,
MK Jeffcoat,
ML Kaplan,
P Goldhaber,
HG Johnson,
and
WJ Wechter
The nonsteroidal anti-inflammatory drug, flurbiprofen, a potent cyclooxygenase inhibitor, significantly decreases the resorption of alveolar bone in naturally occurring chronic destructive periodontal disease in beagles. This observation indicates that arachidonic acid metabolites are important in the alveolar bone loss of periodontitis and suggests a use for flurbiprofen in the management of bone resorption disease.
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