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Science 8 February 1985:
Vol. 227. no. 4687, pp. 638 - 640
DOI: 10.1126/science.2857500
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Articles

Science, Vol 227, Issue 4687, 638-640
Copyright © 1985 by American Association for the Advancement of Science

articles

Early biochemical effects of an organic mercury fungicide on infants: "dose makes the poison"

CA Gotelli, E Astolfi, C Cox, E Cernichiari, and TW Clarkson

Phenylmercury absorbed through the skin from contaminated diapers affected urinary excretion in infants in Buenos Aires. The effects were reversible and quantitatively related to the concentration of urinary mercury. Excretion of gamma-glutamyl transpeptidase, an enzyme in the brush borders of renal tubular cells, increased in a dose-dependent manner when mercury excretion exceeded a "threshold" value. Urine volume also increased but at a higher threshold with respect to mercury. The results support the threshold concept of the systemic toxicity of metals. gamma-Glutamyl transpeptidase is a useful and sensitive marker for preclinical effects of toxic metals.


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Technical Report: Mercury in the Environment: Implications for Pediatricians.
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Molecular Interactions with Mercury in the Kidney.
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Pharmacol. Rev. 52, 113-144
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DMPS (2,3-Dimercaptopropane-1-sulfonate, Dimaval) Decreases the Body Burden of Mercury in Humans Exposed to Mercurous Chloride.
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Principles of Risk Assessment.
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Advances in Dental Research 6, 22-27
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